Omega-3 Fatty Acids and Their Interaction with the Gut Microbiome in the Prevention and Amelioration of Type-2 Diabetes

被引：29

作者：

Kumar, Manoj ^{[1
]}

Pal, Namrata ^{[1
]}

Sharma, Poonam ^{[1
]}

Kumawat, Manoj ^{[1
]}

Sarma, Devojit Kumar ^{[1
]}

Nabi, Bilkees ^{[2
]}

Verma, Vinod ^{[3
]}

Tiwari, Rajnarayan R. ^{[1
]}

Shubham, Swasti ^{[1
]}

Arjmandi, Bahram ^{[4
]}

Nagpal, Ravinder ^{[4
]}

机构：

[1] Natl Inst Res Environm Hlth, Bhopal 462030, India

[2] Sam Higginbottom Univ Agr Technol & Sci, Dept Biochem & Biochem Engn, Allahabad 211007, Uttar Pradesh, India

[3] Sanjay Gandhi Postgrad Inst Med Sci, Stem Cell Res Ctr, Dept Hematol, Lucknow 226014, Uttar Pradesh, India

[4] Florida State Univ, Dept Nutr & Integrat Physiol, Tallahassee, FL 32302 USA

来源：

NUTRIENTS | 2022年 / 14卷 / 09期

关键词：

diabetes mellitus; gut; omega-3 fatty acids; eicosapentaenoic acid; docosahexaenoic acid; alpha-linolenic acid; microbiota; POLYUNSATURATED FATTY-ACIDS; INSULIN-RESISTANCE; EICOSAPENTAENOIC ACID; MEDITERRANEAN DIET; HEPATIC STEATOSIS; LIVER-DISEASE; SUPPLEMENTATION; OMEGA-3; MELLITUS; INFLAMMATION;

D O I：

10.3390/nu14091723

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Type-2 diabetes mellitus (T2DM) is often linked with hyperglycemia, disturbed lipid profiles, inflammation, and gut dysbiosis. Omega-3 fatty acid supplementation has a vital role in the management of T2DM. As a result, a better understanding of the potential role of omega-3 fatty acids in the development and progression of T2DM by influencing the intestinal microflora will help to improve the therapeutic intervention for T2DM and related complications. Focusing on the molecular mechanisms and signaling pathways induced by omega-3 fatty acids, this paper attempts to comprehensively review and discuss the putative associations between omega-3 fatty acids, gut dysbiosis, and the pathophysiology of T2DM and its related comorbidities. In addition, we contemplate the importance of gut microbiota in T2DM prevention and treatment and ponder the role of omega-3 fatty acids in T2DM by positively modulating gut microbiota, which may lead to discovery of novel targets and therapeutic strategies thereby paving way for further comprehensive, mechanistic, and clinical studies.

引用

页数：14

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