Drug delivery systems: Anticancer prodrugs and their polymeric conjugates

被引：14
|
作者：
Greenwald, RB
机构：
[1] Enzon, Inc., Piscataway, NJ 08854
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 1997年 / 7卷 / 06期
关键词：
D O I：
10.1517/13543776.7.6.601
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Prodrugs and their polymeric conjugates (transport forms) offer many promising modalities for new cancer chemotherapies. They present unique opportunities to increase the therapeutic index of a particular drug by exploiting the properties associated with the disease in a predictable fashion. Drugs can be chemically modified with a promoiety to achieve an exclusive selectivity by utilising specific enzymes, fenestrated vasculatures, more acidic environments and other unique properties of the tumour. Additionally, by incorporating a promoiety into existing immunoconjugates, greater efficacy can be achieved.
引用
收藏
页码：601 / 609
页数：9
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