Drug delivery systems: Anticancer prodrugs and their polymeric conjugates

被引：14

作者：

Greenwald, RB

机构：

[1] Enzon, Inc., Piscataway, NJ 08854

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 1997年 / 7卷 / 06期

关键词：

D O I：

10.1517/13543776.7.6.601

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Prodrugs and their polymeric conjugates (transport forms) offer many promising modalities for new cancer chemotherapies. They present unique opportunities to increase the therapeutic index of a particular drug by exploiting the properties associated with the disease in a predictable fashion. Drugs can be chemically modified with a promoiety to achieve an exclusive selectivity by utilising specific enzymes, fenestrated vasculatures, more acidic environments and other unique properties of the tumour. Additionally, by incorporating a promoiety into existing immunoconjugates, greater efficacy can be achieved.

引用

页码：601 / 609

页数：9