Diastereoselective synthesis of spiro derivatives of 3-substituted 2,3,4,4a,5,6-hexahydro-1H-benzo[c]quinolizines

被引：8
|
作者：
Glukhareva, T. V. [1 ]
Deeva, E. V. [1 ]
Platonova, A. Yu. [1 ]
Geide, I. V. [1 ]
Kodess, M. I. [2 ]
Morzherin, Yu. Yu. [1 ]
机构：
[1] Ural State Tech Univ, Ekaterinburg 620002, Russia
[2] Russian Acad Sci, Ural Div, Postovskii Inst Organ Synth, Moscow 117901, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 45卷 / 05期
关键词：
IN-SITU; AMINO;
D O I：
10.1134/S1070428009050170
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cyclization via the mechanism of "tert-amino effect" of 2-(4-R-piperidino)benzaldehydes with cyclic active methylene components (Meldrum's acid, 1,3-cyclohexanedione, and N,N-disubstituted barbituric acids) proceeded stereoselectively giving spiro-joined 2,3,4,4a,5,6-hexahydro-1H-benzo[c]quinolizines with axially oriented hydrogen atoms in the positions 3 and 4a of the benzo[c]quinolizine ring.
引用
收藏
页码：743 / 754
页数：12
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