Synthesis and characterization of thermo- and pH-sensitive block copolymers bearing a biotin group at the poly(ethylene oxide) chain end

被引：14
|
作者：
Tong, Dajun [1 ]
Yao, Jia [1 ]
Li, Haoran [1 ]
Han, Shijun [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2006年 / 102卷 / 04期
关键词：
H2N-PEO-PDMAEMA; anionic polymerization; block copolymer; biotin; site-specific drug delivery;
D O I：
10.1002/app.24812
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A poly(ethylene oxide)-block-poly(dimethylamino ethyl methacrylate) block copolymer (PEO-b-PDMAEMA) bearing an amino moiety at the PEO chain end was synthesized by a one-pot sequential oxyanionic polymerization of ethylene oxide (EO) and dimethylamino ethyl methacrylate (DMAEMA), followed by a coupling reaction between its PEO amino and a biotin derivative. The polymers were characterized with H-1 NMR spectroscopy and gel permeation chromatography. Activated biotin, biotin-NHS (N-hydroxysucci-nimide), was used to synthesize biotin-PEO-PDMAEMA. In aqueous media, the solubility of the copolymer was temperature- and pH-sensitive. The particle size of the micelle formed from functionalized block copolymers was determined by dynamic light scattering. (c) 2006 Wiley Periodicals, Inc.
引用
收藏
页码：3552 / 3558
页数：7
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