Approval of brexucabtagene autoleucel for adults with relapsed and refractory acute lymphocytic leukemia

被引：36

作者：

Frey, Noelle, V ^{[1
]}

机构：

[1] Hosp Univ Penn, Abramson Canc Ctr, Div Hematol Oncol, Cell Therapy & Transplant, 3400 Spruce St, Philadelphia, PA 19104 USA

来源：

BLOOD | 2022年 / 140卷 / 01期

关键词：

CAR-T-CELLS; B-CELL; YOUNG-ADULTS; THERAPY; CHILDREN;

D O I：

10.1182/blood.2021014892

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In October 2021, brexucabtagene autoleucel became the first anti-CD19 chimeric antigen receptor T-cell product to receive approval from the Food and Drug Administration to treat adults with relapsed and refractory B-cell acute lymphoblastic leukemia. The approval is based on results from the Zuma-3 trial and significantly widens treatment options for this patient population. In this article, we review outcomes from this study and its implications.

引用

页码：11 / 15

页数：5

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