Antenatal Medical Therapies to Improve Lung Development in Congenital Diaphragmatic Hernia

被引：16

作者：

Kashyap, Aidan ^{[1
,2
]}

DeKoninck, Philip ^{[1
,2
]}

Crossley, Kelly ^{[1
,2
]}

Thio, Marta ^{[3
,4
,5
,6
]}

Polglase, Graeme ^{[1
,2
]}

Russo, Francesca Maria ^{[7
,8
]}

Deprest, Jan ^{[7
,8
,9
]}

Hooper, Stuart ^{[1
,2
]}

Hodges, Ryan ^{[1
,2
,10
]}

机构：

[1] Hudson Inst Med Res, Ritchie Ctr, Melbourne, Vic, Australia

[2] Monash Univ, Dept Obstet & Gynaecol, Melbourne, Vic, Australia

[3] Royal Womens Hosp, Newborn Res Ctr, Melbourne, Vic, Australia

[4] Murdoch Childrens Res Inst, Ctr Res Excellence Newborn Med, Melbourne, Vic, Australia

[5] Univ Melbourne, Dept Obstet & Gynaecol, Melbourne, Vic, Australia

[6] Royal Childrens Hosp, PIPER Neonatal Retrieval Serv Victoria, Melbourne, Vic, Australia

[7] Univ Hosp Leuven, Div Woman & Child, Dept Obstet & Gynaecol, Leuven, Belgium

[8] Katholieke Univ Leuven, Cluster Woman & Child, Fac Med, Dept Dev & Regenerat, Leuven, Belgium

[9] Univ Coll London Hosp, Inst Womens Hlth, London, England

[10] Monash Hlth, Monash Womens Serv, Melbourne, Vic, Australia

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2018年 / 35卷 / 09期

关键词：

congenital diaphragmatic hernia; antenatal therapy; fetal; sildenafil; pulmonary hypertension of the newborn; pulmonary hypoplasia; PERSISTENT PULMONARY-HYPERTENSION; ENDOSCOPIC TRACHEAL OCCLUSION; FETAL BREATHING MOVEMENTS; SILDENAFIL CITRATE THERAPY; FLUID STEM-CELLS; VITAMIN-A; PRENATAL GLUCOCORTICOIDS; ORAL SILDENAFIL; NITROFEN MODEL; RABBIT MODEL;

D O I：

10.1055/s-0037-1618603

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Congenital diaphragmatic hernia (CDH) is a birth defect characterized by failed closure of the diaphragm, allowing abdominal viscera to herniate into the thoracic cavity and subsequently impair pulmonary and vascular development. Despite improving standardized postnatal management, there remains a population of severe CDH for whom postnatal care falls short. In these severe cases, antenatal surgical intervention (fetoscopic endoluminal tracheal occlusion [FETO]) may improve survival; however, FETO increases the risk of preterm delivery, is not widely offered, and still fails in half of cases. Antenatal medical therapies that stimulate antenatal pulmonary development are therefore interesting alternatives. By presenting the animal research underpinning novel antenatal medical therapies for CDH, and considering the applications of these therapies to clinical practice, this review will explore the future of antenatal CDH management with a focus on the phosphodiesterase-5 inhibitor sildenafil.

引用

页码：823 / 836

页数：14

共 138 条

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