Longitudinal Changes in the Cerebral Cortex Functional Organization of Healthy Elderly

被引：79

作者：

Chong, Joanna Su Xian ^{[1
]}

Ng, Kwun Kei ^{[1
]}

Tandi, Jesisca ^{[1
]}

Wang, Chenhao ^{[1
]}

Poh, Jia-Hou ^{[1
]}

Lo, June C. ^{[1
]}

Chee, Michael W. L. ^{[1
]}

Zhou, Juan Helen ^{[1
,2
]}

机构：

[1] Duke Natl Univ Singapore Med Sch, Ctr Cognit Neurosci, Neurosci & Behav Disorders Programme, Singapore 169857, Singapore

[2] Natl Univ Singapore, Clin Imaging Res Ctr, Singapore 117599, Singapore

来源：

JOURNAL OF NEUROSCIENCE | 2019年 / 39卷 / 28期

基金：

英国医学研究理事会;

关键词：

aging; fMRI; functional connectivity; functional segregation; longitudinal changes; AGE-RELATED-CHANGES; RESTING-STATE NETWORKS; DEFAULT-MODE NETWORK; BRAIN NETWORKS; INDIVIDUAL-DIFFERENCES; ALZHEIMERS-DISEASE; MENTAL STATE; CONNECTIVITY; ARCHITECTURE; FMRI;

D O I：

10.1523/JNEUROSCI.1451-18.2019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Healthy aging is accompanied by disruptions in the functional modular organization of the human brain. Cross-sectional studies have shown age-related reductions in the functional segregation and distinctiveness of brain networks. However, less is known about the longitudinal changes in brain functional modular organization and their associations with aging-related cognitive decline. We examined age-and aging-related changes in functional architecture of the cerebral cortex using a dataset comprising a cross-sectional healthy young cohort of 57 individuals (mean +/- SD age, 23.71 +/- 3.61 years, 22 males) and a longitudinal healthy elderly cohort of 72 individuals (mean +/- baseline age, 68.22 +/- 5.80 years, 39 males) with 2-3 time points (18-24 months apart) of task-free fMRI data. We found both cross-sectional (elderly vs young) and longitudinal (in elderly) global decreases in network segregation (decreased local efficiency), integration (decreased global efficiency), and module distinctiveness (increased participation coefficient and decreased system segregation). At the modular level, whereas cross-sectional analyses revealed higher participation coefficient across all modules in the elderly compared with young participants, longitudinal analyses revealed focal longitudinal participation coefficient increases in three higher-order cognitive modules: control network, default mode network, and salience/ventral attention network. Cross-sectionally, elderly participants also showed worse attention performance with lower local efficiency and higher mean participation coefficient, and worse global cognitive performance with higher participation coefficient in the dorsal attention/control network. These findings suggest that healthy aging is associated with whole-brain connectome-wide changes in the functional modular organization of the brain, accompanied by loss of functional segregation, particularly in higher-order cognitive networks.

引用

页码：5534 / 5550

页数：17

共 91 条

[71] Age-related differences in activation-performance relations in delayed-response tasks: A multiple component analysis [J].

Rypma, Bart ;

Eldreth, Dana A. ;

Rebbechi, Donovan .

CORTEX, 2007, 43 (01) :65-76

[72] Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI [J].

Schaefer, Alexander ;

Kong, Ru ;

Gordon, Evan M. ;

Laumann, Timothy O. ;

Zuo, Xi-Nian ;

Holmes, Avram J. ;

Eickhoff, Simon B. ;

Yeo, B. T. Thomas .

CEREBRAL CORTEX, 2018, 28 (09) :3095-3114

[73]

SCHAIE K W, 1965, Psychol Bull, V64, P92, DOI 10.1037/h0022371

[74]

Schaie K.W., 1996, Intellectual development in adulthood: The Seattle longitudinal study

[75]

Schaie K Warner, 2005, Res Hum Dev, V2, P133, DOI 10.1207/s15427617rhd0203_4

[76] Neurodegenerative Diseases Target Large-Scale Human Brain Networks [J].

Seeley, William W. ;

Crawford, Richard K. ;

Zhou, Juan ;

Miller, Bruce L. ;

Greicius, Michael D. .

NEURON, 2009, 62 (01) :42-52

[77]

SHEIKH J I, 1986, Clinical Gerontologist, V5, P165

[78]

Singh J. K., 2003, Artificial breeding and reproduction management in buffaloes: compendium of the lectures delivered in the Indian Council of Agricultural Research, Summer School, Central Institute for Research on Buffaloes, Sirsa Road, Hisar, Haryana, India, 10-30 June 2003, P127

[79]

Smith A., 1991, Symbol digit modalities test

[80] Correspondence of the brain's functional architecture during activation and rest [J].

Smith, Stephen M. ;

Fox, Peter T. ;

Miller, Karla L. ;

Glahn, David C. ;

Fox, P. Mickle ;

Mackay, Clare E. ;

Filippini, Nicola ;

Watkins, Kate E. ;

Toro, Roberto ;

Laird, Angela R. ;

Beckmann, Christian F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (31) :13040-13045

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