CAR-T cells are serial killers

被引：15

作者：

Davenport, Alexander J. ^{[1
,2
,3
]}

Jenkins, Misty R. ^{[1
,2
]}

Ritchie, David S. ^{[1
,2
,3
]}

Prince, H. Miles ^{[4
]}

Trapani, Joseph A. ^{[1
,2
]}

Kershaw, Michael H. ^{[1
,2
]}

Darcy, Phillip K. ^{[1
,2
]}

Neeson, Paul J. ^{[1
,2
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Immunol Res, East Melbourne, Vic, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3052, Australia

[3] Royal Melbourne Hosp, ACRF Translat Res Lab, Parkville, Vic 3050, Australia

[4] Peter MacCallum Canc Ctr, Dept Canc Med, East Melbourne, Vic, Australia

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 12期

基金：

英国医学研究理事会;

关键词：

CAR; serial killing; T cell therapy;

D O I：

10.1080/2162402X.2015.1053684

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.

引用

页数：2

共 8 条

[1] CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells [J].

Davenport, Alexander J. ;

Jenkins, Misty R. ;

Cross, Ryan S. ;

Yong, Carmen S. ;

Prince, H. Miles ;

Ritchie, David S. ;

Trapani, Joseph A. ;

Kershaw, Michael H. ;

Darcy, Phillip K. ;

Neeson, Paul J. .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (05) :483-494

[2] Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia [J].

Grupp, Stephan A. ;

Kalos, Michael ;

Barrett, David ;

Aplenc, Richard ;

Porter, David L. ;

Rheingold, Susan R. ;

Teachey, David T. ;

Chew, Anne ;

Hauck, Bernd ;

Wright, J. Fraser ;

Milone, Michael C. ;

Levine, Bruce L. ;

June, Carl H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (16) :1509-1518

[3] CAR T Cells for Solid Tumors Armed and Ready to Go? [J].

Kakarla, Sunitha ;

Gottschalk, Stephen .

CANCER JOURNAL, 2014, 20 (02) :151-155

[4] Gene-engineered T cells for cancer therapy [J].

Kershaw, Michael H. ;

Westwood, Jennifer A. ;

Darcy, Phillip K. .

NATURE REVIEWS CANCER, 2013, 13 (08) :525-541

[5]

Liadi I, 2015, CANCER IMMUNOL RES, P1

[6] Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack [J].

Lopez, Jamie A. ;

Susanto, Olivia ;

Jenkins, Misty R. ;

Lukoyanova, Natalya ;

Sutton, Vivien R. ;

Law, Ruby H. P. ;

Johnston, Angus ;

Bird, Catherina H. ;

Bird, Phillip I. ;

Whisstock, James C. ;

Trapani, Joseph A. ;

Saibil, Helen R. ;

Voskoboinik, Ilia .

BLOOD, 2013, 121 (14) :2659-2668

[7] Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia [J].

Porter, David L. ;

Levine, Bruce L. ;

Kalos, Michael ;

Bagg, Adam ;

June, Carl H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (08) :725-733

[8] Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma [J].

Pule, Martin A. ;

Savoldo, Barbara ;

Myers, G. Doug ;

Rossig, Claudia ;

Russell, Heidi V. ;

Dotti, Gianpietro ;

Huls, M. Helen ;

Liu, Enli ;

Gee, Adrian P. ;

Mei, Zhuyong ;

Yvon, Eric ;

Weiss, Heidi L. ;

Liu, Hao ;

Rooney, Cliona M. ;

Heslop, Helen E. ;

Brenner, Malcolm K. .

NATURE MEDICINE, 2008, 14 (11) :1264-1270

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