Seborrheic Dermatitis Is Related to Motor Symptoms in Parkinson's Disease

被引:12
作者
Tomic, Svetlana [1 ,2 ]
Kuric, Igor [2 ,3 ]
Kuric, Tihana Gilman [1 ,2 ]
Popovic, Zvonimir [1 ,2 ]
Kragujevic, Jagoda [1 ,4 ]
Zubonja, Tea Mirosevic [1 ,2 ]
Rajkovaca, Ines [2 ,5 ]
Matosa, Sara [1 ]
机构
[1] Osijek Univ Hosp Ctr, Dept Neurol, Osijek, Croatia
[2] Josip Juraj Strossmayer Univ Osijek, Fac Med, Osijek, Croatia
[3] Osijek Univ Hosp Ctr, Dept Dermatol & Venereol, Osijek, Croatia
[4] Josip Juraj Strossmayer Univ Osijek, Fac Dent Med & Hlth, Osijek, Croatia
[5] Dr Josip Bencevic Gen Hosp, Dept Gastroenterol, Slavonski Brod, Croatia
来源
JOURNAL OF CLINICAL NEUROLOGY | 2022年 / 18卷 / 06期
关键词
Parkinson's disease; seborrheic dermatitis; motor symptoms; nonmotor symptoms; levodopa-equivalent daily dose; L-DOPA; SKIN DISORDERS; SCALE; SEBUM;
D O I
10.3988/jcn.2022.18.6.628
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose Parkinson's disease (PD) patients present with numerous motor and nonmotor symptoms. Seborrheic dermatitis (SD) is reported in 18.6%-59% of PD patients. However, the etiology of SD in PD patients remains unknown. The aim of this study was to determine how motor and nonmotor symptoms, age, sex, and levodopa-equivalent daily dose (LEDD) influence the appearance and severity of SD in PD patients, and then discuss about SD possible etiology based on the obtained results. Methods Motor symptoms were evaluated using the Unified Parkinson's Disease Rating Scale part III and nonmotor symptoms were evaluated using the Parkinson's Disease Sleep Scale, Scales for Outcomes in Parkinson's Disease-Autonomic Dysfunction, and Non-Motor Symptoms Questionnaire. LEDD was calculated and demographic data on age, sex, disease duration, and symptoms of SD prior to a PD diagnosis were collected. A dermatologist evaluated the skin for SD using the Seborrhea Area and Severity Index. Results SD was present in 36.1% of the PD patients. There were positive correlations between age, motor-symptoms severity, and SD. After adjusting for age, disease duration, and sex, there remained a positive correlation between the severity of motor symptoms and SD. Patients with moderate-to-severe motor symptoms had more-severe SD symptoms, and their risk of developing SD was 1.8-fold higher. There was no correlation between SD and autonomic dysfunction, sleep disturbances, or other nonmotor symptoms, and no sex difference. Conclusions In PD, SD is related to motor symptoms.
引用
收藏
页码:628 / 634
页数:7
相关论文
共 31 条
[11]  
Elewski BE, 2009, CUTIS, V83, P333
[12]  
Fahn S., 1987, Recent developments in parkinsons disease, V1st
[13]   Skin function and skin disorders in Parkinson's disease [J].
Fischer, M ;
Gemende, I ;
Marsch, WC ;
Fischer, PA .
JOURNAL OF NEURAL TRANSMISSION, 2001, 108 (02) :205-213
[14]   The Unified Parkinson's Disease Rating Scale (UPDRS): Status and recommendations [J].
Goetz, CG ;
Poewe, W ;
Rascol, O ;
Sampaio, C ;
Stebbins, GT ;
Fahn, S ;
Lang, AE ;
Martinez-Martin, P ;
Tilley, B ;
Van Hilten, B ;
Kleczka, C ;
Seidl, L .
MOVEMENT DISORDERS, 2003, 18 (07) :738-750
[15]   Seborrheic dermatitis [J].
Gupta, AK ;
Bluhm, R ;
Cooper, EA ;
Summerbell, RC ;
Batra, R .
DERMATOLOGIC CLINICS, 2003, 21 (03) :401-+
[16]   SEBACEOUS GLAND SECRETION IN PARKINSONS-DISEASE DURING L-DOPA TREATMENT [J].
KOHN, SR ;
POCHI, PE ;
STRAUSS, JS ;
SAX, DS ;
FELDMAN, RG ;
TIMBERLAKE, WH .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1973, 60 (03) :134-136
[17]  
MacMahon D., 2004, ACNR, V4, P20
[18]  
MAIETTA G, 1990, ACTA DERM-VENEREOL, V70, P432
[19]   Is seborrhea a sign of autonomic impairment in Parkinson's disease? [J].
Martignoni, E ;
Godi, L ;
Pacchetti, C ;
Berardesca, E ;
Vignoli, GP ;
Albani, G ;
Mancini, F ;
Nappi, G .
JOURNAL OF NEURAL TRANSMISSION, 1997, 104 (11-12) :1295-1304
[20]   Seborrheic dermatitis, increased sebum excretion, and Parkinson's disease: a survey of (im)possible links [J].
Mastrolonardo, M ;
Diaferio, A ;
Logroscino, G .
MEDICAL HYPOTHESES, 2003, 60 (06) :907-911