Kynurenine pathway in depression: A systematic review and meta-analysis

被引：216

作者：

Ogyu, Kamiyu ^{[1
]}

Kubo, Kaoruhiko ^{[1
]}

Noda, Yoshihiro ^{[1
]}

Iwata, Yusuke ^{[2
]}

Tsugawa, Sakiko ^{[3
]}

Omura, Yuki ^{[3
]}

Wada, Masataka ^{[1
]}

Tarumi, Ryosuke ^{[1
]}

Plitman, Eric ^{[2
]}

Moriguchi, Sho ^{[2
]}

Miyazaki, Takahiro ^{[1
]}

Uchida, Hiroyuki ^{[1
]}

Graff-Guerrero, Ariel ^{[2
]}

Mimura, Masaru ^{[1
]}

Nakajima, Shinichiro ^{[1
,2
]}

机构：

[1] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan

[2] Univ Toronto, Ctr Addict & Mental Hlth, Res Imaging Ctr, Multimodal Imaging Grp, Toronto, ON, Canada

[3] Keio Univ, Sch Med, Tokyo, Japan

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2018年 / 90卷

基金：

日本学术振兴会;

关键词：

Depression; Glutamate; Kynurenic acid; N-methyl-D-aspartate receptor; Neuroinflammation; Quinolinic acid; MAJOR DEPRESSION; ELECTROCONVULSIVE-THERAPY; PREFRONTAL CORTEX; IMMUNE-SYSTEM; ACID; TRYPTOPHAN; GLUTAMATE; DISORDER; ANTIDEPRESSANT; INFLAMMATION;

D O I：

10.1016/j.neubiorev.2018.03.023

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Abnormalities of the kynurenine (KYN) pathway may be implicated in the pathophysiology of depression. However, the relationships between depression and each metabolite of the KYN pathway remain uncertain. Therefore, we conducted a meta-analysis about the levels of the metabolites of KYN pathway between patients with depression and controls. Out of 899 initial records, we identified 22 articles to form the empirical basis. Seventeen, 10, and 18 studies examined levels of kynurenic acid (KYNA), quinolinic acid (QUIN), and KYN, respectively. KYNA and KYN levels were lower in patients with depression in comparison to controls, while QUIN levels did not differ between the two groups. Antidepressant-free patients showed decreased KYNA levels and increased QUIN levels compared with controls. Male ratios of the samples were negatively associated with study SMDs for KYNA. In conclusion, this meta-analysis revealed that patients with depression had decreased level of KYNA and KYN, whereas antidepressant-free patients showed increased level of QUIN. Nevertheless, given the heterogeneity among their sample characteristics, further research is clearly needed.

引用

页码：16 / 25

页数：10

共 76 条

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