Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization

被引：15

作者：

Mukherjee, Jyotiprasad ^{[1
]}

Sil, Suman ^{[1
]}

Chattopadhyay, Shital Kumar ^{[1
]}

机构：

[1] Univ Kalyani, Dept Chem, Kalyani 741235, W Bengal, India

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 11卷

关键词：

cross metathesis; cyclic peptides; diversity oriented synthesis; macrocycle; HISTONE DEACETYLASE INHIBITORS; NATURAL-PRODUCTS; CHEMISTRY;

D O I：

10.3762/bjoc.11.270

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthetic approach to a class of biologically interesting cyclic tetrapeptides is reported which involves a late-stage functionalization of a macrocyclic scaffold through cross metathesis in an attempt to create diversity. The utility of this protocol is demonstrated through the preparation of three structural analogues of the important naturally occurring histone deacetylase inhibitor FR-225497.

引用

页码：2487 / 2492

页数：6

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