TAFRO Syndrome with Disseminated Intravascular Coagulation Successfully Treated with Tocilizumab and Recombinant Thrombomodulin

被引：14

作者：

Takayama, Yusuke ^{[1
]}

Kubota, Tetsuya ^{[1
]}

Ogino, Yoshitaka ^{[1
]}

Ohnishi, Hiroshi ^{[1
]}

Togitani, Kazuto ^{[1
]}

Yokoyama, Akihito ^{[1
]}

机构：

[1] Kochi Univ, Kochi Med Sch, Dept Hematol & Resp Med, Kochi, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 09期

关键词：

TAFRO syndrome; disseminated intravascular coagulation; tocilizumab; recombinant thrombomodulin; MULTICENTRIC CASTLEMANS-DISEASE; RECEPTOR ANTIBODY; KOJIMA DISEASE; THROMBOCYTOPENIA; ANASARCA; MYELOFIBROSIS; ASCITES; FEVER; LYMPHADENOPATHY; CONSTELLATION;

D O I：

10.2169/internalmedicine.9484-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

TAFRO syndrome is a systemic inflammatory disorder that is characterized by thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly. Although thrombocytopenia is one of the major features of TAFRO syndrome, complications of disseminated intravascular coagulation (DIC) are not common. The therapeutic strategy for TAFRO syndrome complicated by DIC has not been established. We herein describe a case of TAFRO syndrome with DIC that was successfully treated with tocilizumab (an anti-IL-6 receptor antibody) and recombinant thrombomodulin (rTM). This case suggests a possible therapeutic benefit of rTM in patients with TAFRO syndrome complicated by DIC.

引用

页码：1291 / 1296

页数：6

共 18 条

[1] Classifying types of disseminated intravascular coagulation: Clinical and animal models [J].

Asakura H. .

Journal of Intensive Care, 2 (1)

[2] A Case of Multicentric Castleman's Disease of Mixed-Type, which Showed Constellation of Symptoms, i.e., Thrombocytopenia, Anasarca, Anemia, Fever, Myelofibrosis, and Lymphadenopathy [J].

Awano, Nobuyasu ;

Inomata, Minoru ;

Sonoda, Yui ;

Kondoh, Keisuke ;

Ono, Ryu ;

Moriya, Atsuko ;

Ando, Tsunehiro ;

Kumasaka, Toshio ;

Takemura, Tamiko ;

Takeuchi, Kengo ;

Ikushima, Soichiro .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2013, 53 (01) :101-105

[3] HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy [J].

Fajgenbaum, David C. ;

van Rhee, Frits ;

Nabel, Christopher S. .

BLOOD, 2014, 123 (19) :2924-2933

[4] Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy, with anti-IL-6 receptor antibody and steroids [J].

Fujiwara, Shiho ;

Mochinaga, Hiromi ;

Nakata, Hirotomo ;

Ohshima, Koichi ;

Matsumoto, Masanori ;

Uchiba, Mitsuhiro ;

Mikami, Yoshiki ;

Hata, Hiroyuki ;

Okuno, Yutaka ;

Mitsuya, Hiroaki ;

Nosaka, Kisato .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2016, 103 (06) :718-723

[5] Complete Resolution of TAFRO Syndrome (Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis and Organomegaly) after Immunosuppressive Therapies using Corticosteroids and Cyclosporin A : A Case Report [J].

Inoue, Morihiro ;

Ankou, Mayuka ;

Hua, Jiang ;

Iwaki, Yasunobu ;

Hagihara, Masao ;

Ota, Yasunori .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2013, 53 (01) :95-99

[6] Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease [J].

Iwaki, Noriko ;

Fajgenbaum, David C. ;

Nabel, Christopher S. ;

Gion, Yuka ;

Kondo, Eisei ;

Kawano, Mitsuhiro ;

Masunari, Taro ;

Yoshida, Isao ;

Moro, Hiroshi ;

Nikkuni, Koji ;

Takai, Kazue ;

Matsue, Kosei ;

Kurosawa, Mitsutoshi ;

Hagihara, Masao ;

Saito, Akio ;

Okamoto, Masataka ;

Yokota, Kenji ;

Hiraiwa, Shinichiro ;

Nakamura, Naoya ;

Nakao, Shinji ;

Yoshino, Tadashi ;

Sato, Yasuharu .

AMERICAN JOURNAL OF HEMATOLOGY, 2016, 91 (02) :220-226

[7] Atypical Hyaline Vascular-Type Castleman's Disease With Thrombocytopenia, Anasarca, Fever, and Systemic Lymphadenopathy [J].

Iwaki, Noriko ;

Sato, Yasuharu ;

Takata, Katsuyoshi ;

Kondo, Eisei ;

Ohno, Kyotaro ;

Takeuchi, Mai ;

Orita, Yorihisa ;

Nakao, Shinji ;

Yoshino, Tadashi .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2013, 53 (01) :87-93

[8] Successful Treatment of a Patient with Multicentric Castleman's Disease who Presented with Thrombocytopenia, Ascites, Renal Failure and Myelofibrosis Using Tocilizumab, an Anti-Interleukin-6 Receptor Antibody [J].

Kawabata, Hiroshi ;

Kotani, Shin-ichi ;

Matsumura, Yumi ;

Kondo, Tadakazu ;

Katsurada, Tatsuya ;

Haga, Hironori ;

Kadowaki, Norimitsu ;

Takaori-Kondo, Akifumi .

INTERNAL MEDICINE, 2013, 52 (13) :1503-1507

[9] Clinical Features and Treatment of Multicentric Castleman's Disease : A Retrospective Study of 21 Japanese Patients at a Single Institute [J].

Kawabata, Hiroshi ;

Kadowaki, Norimitsu ;

Nishikori, Momoko ;

Kitawaki, Toshio ;

Kondo, Tadakazu ;

Ishikawa, Takayuki ;

Yoshifuji, Hajime ;

Yamakawa, Noriyuki ;

Imura, Yoshitaka ;

Mimori, Tsuneyo ;

Matsumura, Yumi ;

Miyachi, Yoshiki ;

Matsubara, Takeshi ;

Yanagita, Motoko ;

Haga, Hironori ;

Takaori-Kondo, Akifumi .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2013, 53 (01) :69-77

[10] Castleman-Kojima Disease (TAFRO Syndrome) : A Novel Systemic Inflammatory Disease Characterized by a Constellation of Symptoms, Namely, Thrombocytopenia, Ascites (Anasarca), Microcytic Anemia, Myelofibrosis, Renal Dysfunction, and Organomegaly : A Status Report and Summary of Fukushima (6 June, 2012) and Nagoya Meetings (22 September, 2012) [J].

Kawabata, Hiroshi ;

Takai, Kazue ;

Kojima, Masaru ;

Nakamura, Naoya ;

Aoki, Sadao ;

Nakamura, Shigeo ;

Kinoshita, Tomohiro ;

Masaki, Yasufumi .

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2013, 53 (01) :57-61

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