CD163+Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma

被引：140
作者：
He, Ke-Fei [1 ,2 ]
Zhang, Lu [1 ,2 ]
Huang, Cong-Fa [1 ,2 ]
Ma, Si-Rui [1 ,2 ]
Wang, Yu-Fan [1 ,2 ]
Wang, Wei-Ming [1 ,2 ]
Zhao, Zhi-Li [1 ,2 ]
Liu, Bing [1 ,2 ,3 ]
Zhao, Yi-Fang [1 ,2 ,3 ]
Zhang, Wen-Feng [3 ]
Sun, Zhi-Jun [1 ,2 ,3 ]
机构：
[1] Wuhan Univ, Minist Educ, State Key Lab Breeding Base Basic Sci Stomatol, Wuhan 430079, Peoples R China
[2] Wuhan Univ, Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Peoples R China
[3] Wuhan Univ, Sch & Hosp Stomatol, Dept Oral Maxillofacial Head Neck Oncol, Wuhan 430079, Peoples R China
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
基金：
中国国家自然科学基金;
关键词：
TUMOR-ASSOCIATED MACROPHAGES; EXPRESSION; CD163; SOX2; RECURRENCE; RESISTANCE; RESPONSES; SURVIVAL; RECEPTOR; TARGET;
D O I：
10.1155/2014/838632
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Tumor-associated macrophages (TAMs) play an important role in the progression and prognostication of numerous cancers. However, the role and clinical significance of TAM markers in oral squamous cell carcinoma (OSCC) has not been elucidated. The present study was designed to investigate the correlation between the expression of TAM markers and pathological features in OSCC by tissue microarray. Tissue microarrays containing 16 normal oral mucosa, 6 oral epithelial dysplasia, and 43 OSCC specimens were studied by immunohistochemistry. We observed that the protein expression of the TAM markers CD68 and CD163 as well as the cancer stem cell (CSC) markers ALDH1, CD44, and SOX2 increased successively from the normal oral mucosa to OSCC. The expressions of CD68 and CD163 were significantly associated with lymph node status, and SOX2 was significantly correlated with pathological grade and lymph node status, whereas ALDH1 was correlated with tumor stage. Furthermore, CD68 was significantly correlated with CD163, SOX2, and ALDH1 (P < 0.05). Kaplan-Meier analysis revealed that OSCC patients overexpressing CD163 had significantly worse overall survival (P < 0.05). TAM markers are associated with cancer stem cell marker and OSCC overall survival, suggesting their potential prognostic value in OSCC.
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页数：9
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