Esterase-activated release of naproxen from supramolecular nanofibres

被引：39

作者：

Conda-Sheridan, Martin ^{[1
]}

Lee, Sungsoo S. ^{[2
]}

Preslar, Adam T. ^{[3
]}

Stupp, Samuel I. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Northwestern Univ, Simpson Querrey Inst BioNanotechnol, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[3] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Med, Chicago, IL 60611 USA

[5] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 89期

基金：

美国国家卫生研究院;

关键词：

PEPTIDE-AMPHIPHILE NANOFIBERS; DRUG-RELEASE; CYCLOOXYGENASE INHIBITION; IN-VITRO; IBUPROFEN; MICELLES; DELIVERY; CANCER; NANOSTRUCTURES; SURVIVAL;

D O I：

10.1039/c4cc06340f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.

引用

页码：13757 / 13760

页数：4

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