Melissa officinalis L. essential oil:: antitumoral and antioxidant activities

被引：138
作者：
de Sousa, AC
Alviano, DS
Blank, AF
Alves, PB
Alviano, CS
Gattass, CR
机构：
[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, CCS BI G, BR-21949900 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo De Gois, Ctr Ciencias Saude, BR-21941900 Rio De Janeiro, Brazil
[3] Univ Fed Sergipe, Dept Engn Agron, Sao Cristovao, SE, Brazil
[4] Univ Fed Sergipe, Dept Quim, Sao Cristovao, SE, Brazil
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 2004年 / 56卷 / 05期
关键词：
D O I：
10.1211/0022357023321
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Melissa officinalis L (lemon balm) is a traditional herbal medicine used widely as a mild sedative, spasmolytic and antibacterial agent. This paper focuses on the analysis of the chemical composition and the biological activities of M. officinalis essential oil obtained under controlled harvesting and drying conditions. An in-vitro cytotoxicity assay using MTT indicated that this oil was very effective against a series of human cancer cell lines (A549, MCF-7, Caco-2, HL-60, K562) and a mouse cell line (B16F10). This oil possessed antioxidant activity, as evidenced by reduction of 1,1-diphenyl-2-picrylhydrazyl (DPPH). These results pointed to the potential use of M. officinalis essential oil as an antitumoral agent.
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收藏
页码：677 / 681
页数：5
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