Serum proteomics for gastric cancer

被引：35

作者：

Liu, Wentao ^{[1
]}

Yang, Qiumeng ^{[1
]}

Liu, Bingya ^{[1
]}

Zhu, Zhenggang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Digest Surg, Key Lab Shanghai Gastr Neoplasms,Dept Surg, Shanghai 200025, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2014年 / 431卷

基金：

中国国家自然科学基金;

关键词：

Gastric cancer; Serum; Biomarker; Proteomics; DIFFERENTIAL GEL-ELECTROPHORESIS; LOW-ABUNDANCE PROTEINS; MASS-SPECTROMETRY; HUMAN PLASMA; PROGNOSTIC-SIGNIFICANCE; PEPTIDOMIC ANALYSIS; BLOOD-SAMPLES; CA; 72-4; IDENTIFICATION; BIOMARKERS;

D O I：

10.1016/j.cca.2014.02.001

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

According to the World Health Organization, 800,000 cancer-related deaths are caused by gastric cancer each year globally, hence making it the second leading cause of cancer-related deaths in the world. Gastric cancer is often either asymptomatic or causing only nonspecific symptoms in its early stages. By the time the symptoms occur, the cancer has usually reached an advanced stage, which is one of the main reasons for its relatively poor prognosis. Therefore, early diagnosis and early treatment are very crucial. The differential analysis of serum protein between cancer patients and healthy controls can be performed using proteomics techniques and can hence be adopted as tumor biomarkers for the early diagnosis of cancer. So far, several serum tumor biomarkers have been identified for gastric cancer. However due to their poor specificity and sensitivity, they have proven to be insufficient for the reliable diagnosis of gastric cancer. Thus, using modem advanced proteomics techniques to find some new and reliable serum tumor biomarkers for earlier and reliable diagnosis of gastric cancer is a must. Nowadays, proteomic-based techniques, such as SEW! and HCLP, are available to discover biomarkers in gastric cancer. Numerous novel serum tumor biomarkers such as SAA, plasminogen and C9c, have been discovered through serological proteomics strategies. This review mainly focuses on the serum proteomics techniques and their application in the research of gastric cancer. (C) 2014 Elsevier B.V. All rights reserved

引用

页码：179 / 184

页数：6

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