The metabolism and anti-atherogenic properties of HDL

被引：236
作者：
Rye, Kerry-Anne [1 ,2 ,3 ]
Bursill, Christina A. [1 ]
Lambert, Gilles [1 ,4 ]
Tabet, Fatiha [1 ]
Barter, Philip J. [1 ,2 ]
机构：
[1] Heart Res Inst, Lipid Res Grp, Sydney, NSW, Australia
[2] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia
[3] Univ Melbourne, Dept Med, Melbourne, Vic 3010, Australia
[4] Univ Nantes, Fac Med, Nantes, France
来源：
JOURNAL OF LIPID RESEARCH | 2009年 / 50卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
HDL remodelling; HDL subpopulations; HDL function; HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; PHOSPHOLIPID TRANSFER PROTEIN; ESTER TRANSFER PROTEIN; LIPASE-MEDIATED HYDROLYSIS; SCAVENGER RECEPTOR BI; ENDOTHELIAL LIPASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; GENE-TRANSFER;
D O I：
10.1194/jlr.R800034-JLR200
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Population studies have shown that plasma HDL levels correlate inversely with cardiovascular disease risk. In recent years there has been intense interest in developing strategies for exploiting these cardioprotective properties by increasing HDL levels. While this approach has considerable merit, it is important to recognize that HDL are structurally and functionally diverse and consist of numerous, highly dynamic subpopulations of particles that do not all inhibit atherosclerosis to the same extent. For this reason it is essential to assess HDL subpopulation distribution and functionality when considering therapeutic interventions that raise HDL levels. jlr This review documents what is known about the relationship between the metabolism and function of HDL subpopulations and how this affects their cardioprotective properties.-Rye, K-A., C. A. Bursill, G. Lambert, F. Tabet, and P. J. Barter. The metabolism and anti-atherogenic properties of HDL. J. Lipid Res. 2009. S195-S200.
引用
收藏
页码：S195 / S200
页数：6
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