Hollow superparamagnetic PLGA/Fe3O4 composite microspheres for lysozyme adsorption

被引：23
作者：
Yang, Qi [1 ]
Wu, Yao [1 ]
Lan, Fang [1 ]
Ma, Shaohua [1 ]
Xie, Liqin [1 ]
He, Bin [1 ]
Gu, Zhongwei [1 ]
机构：
[1] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
来源：
NANOTECHNOLOGY | 2014年 / 25卷 / 08期
基金：
中国国家自然科学基金;
关键词：
superparamagnetic; hollow; microsphere; lysozyme adsorption; NANOCOMPOSITE MICROSPHERES; NANOSPHERES; NANOPARTICLES; SPHERES; SHELL; PARTICLES;
D O I：
10.1088/0957-4484/25/8/085702
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Uniform hollow superparamagnetic poly(lactic-co-glycolic acid) (PLGA)/Fe3O4 composite microspheres composed of an inner cavity, PLGA inner shell and Fe3O4 outer shell have been synthesized by a modified oil-in-water (O/W) emulsion-solvent evaporation method using Fe3O4 nanoparticles as a particulate emulsifier. The obtained composite microspheres with an average diameter of 2.5 mu m showed excellent monodispersity and stability in aqueous medium, strong magnetic responsiveness, high magnetite content (> 68%), high saturation magnetization (58 emu g(-1)) and high efficiency in lysozyme adsorption.
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页数：8
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