MR diffusion tensor Imaging (DTI) and neuropsychological testing for neuronal connectivity in Alzheimer's disease (AD) patients

被引：1

作者：

Zhong, JH ^{[1
]}

Ni, HY ^{[1
]}

Zhu, T ^{[1
]}

Ekholm, S ^{[1
]}

Kavcic, V ^{[1
]}

机构：

[1] Univ Rochester, Rochester, NY 14642 USA

来源：

MEDICAL IMAGING 2004: PHYSIOLOGY, FUNCTION, AND STRUCTURE FROM MEDICAL IMAGES | 2004年 / 5卷 / 23期

关键词：

MRI; Alzheimer's disease; diffusion tensor imaging; neuronal connectivity; corpus callosum; aging;

D O I：

10.1117/12.535752

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We have used MR DTI to identify relevant brain structures involved in visuospatial processing, in an attempt to link perceptual and attentional impairments to WM changes in Alzheimer's disease (AD) patients. Correlation of DTI measured parameters with results of several neuropsychological tests will be reported here. Several issues related to quantitation of DTI parameters in ROI analysis are addressed. In spite of only a small number of subjects were studied so far, we found not only that AD patients showed significant decrease of white matter (WM) integrity in corpus callosum (CC), most prominent at the posterior portion, but also found significant correlations between the DTI parameters and scores from several neuropsychological tests. Our preliminary results suggest that DTI help to improve the overall accuracy rate in distinguishing between early AD onset and age-related functional decline, and potentially may improve efficiency in differentiating between different types of dementia.

引用

页码：238 / 249

页数：12

共 41 条

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