A case of concomitant psoriasis and multiple sclerosis: Secukinumab and rituximab exert dichotomous effects in two autoimmune conditions

被引：12

作者：

Diebold, Martin ^{[1
,2
]}

Mueller, Simon ^{[2
,3
]}

Derfuss, Tobias ^{[1
,2
]}

Decard, Bernhard F. ^{[1
,2
]}

机构：

[1] Univ Hosp, Neurol Clin & Policlin, Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] Univ Hosp, Dept Dermatol, Basel, Switzerland

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2019年 / 31卷

关键词：

Autoimmune diseases; Multiple sclerosis; Psoriasis; Immunomodulation; Monoclonal antibodies; Helper-induced T-lymphocytes; B-lymphocytes;

D O I：

10.1016/j.msard.2019.03.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Multiple sclerosis (MS) and psoriasis vulgaris (PV) are two disorders with autoimmune pathophysiology and a supposed altered T helper (T-H) cell response. Objective: To report a case of concomitant relapsing remitting MS and PV treated with different immunomodulatory medications, particularly secukinumab and rituximab. Methods: Case report. Results: In a 68-year-old woman diagnosed with MS and PV, secukinumab alleviated the dermatological condition, but could not control neuroinflammation. Rituximab treatment halted MS activity, but led to a flare-up of dermatological inflammation. Conclusion: The presented case suggests that the pathomechanisms of MS and PV differ regarding involvement of T-H and B cells with implications for therapeutic approaches.

引用

页码：38 / 40

页数：3