High prevalence of fluoroquinolone-nonsusceptible Streptococcus pyogenes emm12 in Taiwan

被引：10
作者：
Lin, Jiun-Nong [1 ,2 ,3 ]
Chang, Lin-Li [4 ]
Lai, Chung-Hsu [3 ]
Huang, Yi-Han [1 ]
Chen, Wei-Fang [3 ]
Yang, Chih-Hui [5 ]
Hsu, Janine [6 ]
Lin, Hsi-Hsun [3 ]
Chen, Yen-Hsu [7 ,8 ,9 ]
机构：
[1] I Shou Univ, E Da Hosp, Dept Crit Care Med, Kaohsiung, Taiwan
[2] I Shou Univ, Coll Med, Sch Med, Kaohsiung, Taiwan
[3] I Shou Univ, E Da Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan
[4] Kaohsiung Med Univ, Dept Microbiol, Fac Med, Kaohsiung, Taiwan
[5] Meiho Univ, Gen Educ Ctr, Pingtung, Taiwan
[6] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada
[7] Kaohsiung Med Univ, Grad Inst Med, Sch Med, Sepsis Res Ctr,Coll Med, Kaohsiung, Taiwan
[8] Kaohsiung Med Univ Hosp, Div Infect Dis, Dept Internal Med, Kaohsiung, Taiwan
[9] Natl Chiao Tung Univ, Coll Biol Sci & Technol, Dept Biol Sci & Technol, Hsinchu, Taiwan
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2015年 / 83卷 / 02期
关键词：
Streptococcus pyogenes; Group A streptococcus; Fluoroquinolone resistance; Quinolone resistance-determining regions; STREPTOCOCCUS-PYOGENES DISEASE; EMM TYPE; REDUCED SUSCEPTIBILITY; RESISTANT; EPIDEMIOLOGY; IDENTIFICATION; CIPROFLOXACIN; LEVOFLOXACIN; SELECTION; ISOLATE;
D O I：
10.1016/j.diagmicrobio.2015.06.018
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Fluoroquinolone-nonsusceptible Streptococcus pyogenes has rapidly emerged in several countries. The aim of this study was to survey the epidemiology and molecular characteristics of fluoroquinolone-nonsusceptible S. pyogenes in Taiwan. A total of 350 consecutive S. pyogenes isolates were collected between January 2005 and December 2012, including 152 (43.4%) invasive and 198 (56.6%) noninvasive isolates. Thirty-nine isolates (11.1%) of S. pyogenes were nonsusceptible to fluoroquinolones, including one emm1/ST28, 4 emm4/ST39, 33 emm12/ST36, and 1 emm87/5T62. Of all the isolates, emm12 (50%) demonstrated the highest prevalence of fluoroquinolone nonsusceptibility. Alterations of Ser79Phe and Ala12Val in ParC were the most frequently mutations in fluoroquinolone-nonsusceptible S. pyogenes isolates. There were no amino acid substitutions in GyrB, and 1 emm87 isolate exhibited 3 nonsynonymous mutations in ParE. Our study reveals the emergence of fluoroquinolone-nonsusceptible S. pyogenes emm12/ST36 in Taiwan. Regular surveillance of fluoroquinolone susceptibility in S. pyogenes is suggested. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：187 / 192
页数：6
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