Oxidative stress is increased in serum from Mexican patients with relapsing-remitting multiple sclerosis

被引：1

作者：

Gabriel Ortiz, Genaro ^{[1
,2
]}

Angel Macias-Islas, Miguel ^{[3
]}

Pacheco-Moises, Fermin P. ^{[4
]}

Cruz-Ramos, Jose A. ^{[1
]}

Sustersik, Silvia ^{[1
]}

Alejandro Barba, Elias ^{[2
]}

Aguayo, Adriana ^{[5
]}

机构：

[1] CIBO IMSS, Lab Estres Oxidativo & Patol, Div Neurociencias, Guadalajara 44340, Jalisco, Mexico

[2] ITESM, Div Ciencias Salud, Zapopan, Jalisco, Mexico

[3] Univ Guadalajara, CUCS, Dept Neurosci, Guadalajara 44430, Jalisco, Mexico

[4] Univ Guadalajara, Ctr Univ Ciencias Exactas & Ingn, Dept Quim, Guadalajara 44430, Jalisco, Mexico

[5] Fdn Mexicana Esclerosis Multiple AC, Guadalajara, Jalisco, Mexico

来源：

DISEASE MARKERS | 2009年 / 26卷 / 01期

关键词：

Multiple sclerosis; oxidative stress; nitric oxide; lipid peroxidation; glutathione peroxidase; GLUTATHIONE-PEROXIDASE ACTIVITY; NITRIC-OXIDE SYNTHASE; LIPID HYDROPEROXIDES; DIAGNOSTIC-CRITERIA; BLOOD-CELLS; URIC-ACID; SELENIUM;

D O I：

10.1155/2009/325847

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis. Methods: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification. Results: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.

引用

页码：35 / 39

页数：5

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