Advances in radiofrequency ablation of the cerebral cortex in primates using the venous system: Improvements for treating epilepsy with catheter ablation technology

被引：5

作者：

Henz, Benhur D. ^{[1
]}

Friedman, Paul A. ^{[2
]}

Bruce, Charles J. ^{[2
]}

Holmes, David R. ^{[2
]}

Bower, Mark ^{[3
]}

Madhavan, Malini ^{[2
]}

DeSimone, Christopher V. ^{[2
]}

Wahnschaffe, Douglas ^{[4
]}

Berhow, Steven ^{[4
]}

Danielsen, Andrew J. ^{[5
]}

Ladewig, Dorothy J. ^{[5
]}

Mikell, Susan B. ^{[5
]}

Johnson, Susan B. ^{[2
]}

Suddendorf, Scott H. ^{[2
]}

Kara, Tomas ^{[2
,6
]}

Worrell, Gregory A.

Asirvatham, Samuel J. ^{[2
,7
]}

机构：

[1] Inst Brasilia Arritmia, Brasilia, DF, Brazil

[2] Mayo Clin, Dept Internal Med, Div Cardiovasc Dis, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Internal Med, Div Neurol, Rochester, MN 55905 USA

[4] Access Point Technol, Rogers, MN USA

[5] Mayo Clin, Rochester, MN 55905 USA

[6] St Annes Univ Hosp, ICRC, Dept Cardiovasc Dis, Brno, Czech Republic

[7] Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA

来源：

EPILEPSY RESEARCH | 2014年 / 108卷 / 06期

关键词：

Epilepsy; Catheter ablation; Venous system; Radiofrequency; Cerebral cortex; TEMPORAL-LOBE EPILEPSY; PULMONARY VEINS; SURGERY;

D O I：

10.1016/j.eplepsyres.2014.04.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Pharmacology frequently fails for the treatment of epilepsy. Although surgical techniques are effective, these procedures are highly invasive. We describe feasibility and efficacy of minimally invasive mapping and ablation for the treatment of epilepsy. Methods: Mapping and radiofrequency ablations were performed via the venous system in eleven baboons and three dogs. Results: Mapping in deep cerebral areas was obtained in all animals. High-frequency pacing was able to induce seizure activity of local cerebral tissue in 72% of our attempts. Cerebral activity could be seen during mapping. Ablative lesions were deployed at deep brain sites without steam pops or sudden impedance rise. Histologic analysis showed necrosis at the sites of ablation in all primates. Conclusion: Navigation through the cerebral venous system to map seizure activity is feasible. Radiofrequency energy can be delivered transvenously or transcortically to successfully ablate cortical tissue in this animal model using this innovative approach. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1026 / 1031

页数：6

共 12 条

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