ML -: a conserved domain involved in innate immunity and lipid metabolism

被引：205

作者：

Inohara, N ^{[1
]}

Nuñez, G ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol & Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 05期

关键词：

D O I：

10.1016/S0968-0004(02)02084-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a P-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.

引用

页码：219 / 221

页数：3

共 22 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2] PURIFICATION AND CHARACTERIZATION OF AN ACTIVATOR PROTEIN FOR THE DEGRADATION OF GLYCOLIPID-GM2 AND GLYCOLIPID-GA2 BY HEXOSAMINIDASE-A [J].

CONZELMANN, E ;

SANDHOFF, K .

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1979, 360 (12) :1837-1849

[3] Lipid A diversity and the innate host response to bacterial infection [J].

Darveau, RP .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (01) :36-42

[4] A hydrophobic cluster at the surface of the human plasma phospholipid transfer protein is critical for activity on high density lipoproteins [J].

Desrumaux, C ;

Labeur, C ;

Verhee, A ;

Tavernier, J ;

Vandekerckhove, J ;

Rosseneu, M ;

Peelman, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (08) :5908-5915

[5] Solution structure of Der f 2, the major mite allergen for atopic diseases [J].

Ichikawa, S ;

Hatanaka, H ;

Yuuki, T ;

Iwamoto, N ;

Kojima, S ;

Nishiyama, C ;

Ogura, K ;

Okumura, Y ;

Inagaki, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) :356-360

[6] LPS-induced immune response in Drosophila [J].

Imler, JL ;

Tauszig, S ;

Jouanguy, E ;

Forestier, C ;

Hoffmann, JA .

JOURNAL OF ENDOTOXIN RESEARCH, 2000, 6 (06) :459-462

[7] Toll receptors in innate immunity [J].

Imler, JL ;

Hoffmann, JA .

TRENDS IN CELL BIOLOGY, 2001, 11 (07) :304-311

[8] Molecular cloning and characterization of HE1, a major secretory protein of the human epididymis [J].

Kirchhoff, C ;

Osterhoff, C ;

Young, L .

BIOLOGY OF REPRODUCTION, 1996, 54 (04) :847-856

[9] Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line [J].

Kogai, T ;

Schultz, JJ ;

Johnson, LS ;

Huang, M ;

Brent, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (15) :8519-8524

[10] The GM2 activator protein, its roles as a co-factor in GM2 hydrolysis and as a general glycolipid transport protein [J].

Mahuran, DJ .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1998, 1393 (01) :1-18

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