"Hyper-bright" Near-Infrared Emitting Fluorescent Organic Nanoparticles for Single Particle Tracking

被引:66
作者
Genin, Emilie [1 ]
Gao, Zhenghong [3 ,4 ,5 ]
Varela, Juan A. [2 ]
Daniel, Jonathan [1 ]
Bsaibess, Talia [1 ]
Gosse, Isabelle [1 ]
Groc, Laurent [2 ]
Cognet, Laurent [3 ,4 ,5 ]
Blanchard-Desce, Mireille [1 ]
机构
[1] Univ Bordeaux, Inst Mol Sci, UMR 5255, F-33405 Talence, France
[2] Univ Bordeaux, Interdisciplinary Inst Neurosci, UMR 5297, F-33000 Bordeaux, France
[3] Univ Bordeaux, LP2N, UMR 5298, F-33405 Talence, France
[4] Inst Opt, F-33405 Talence, France
[5] CNRS, UMR 5298, F-33405 Talence, France
关键词
luminescence; biocompatibility; photostability; single NP; imaging in cellular environment; CARBON NANOTUBES; THIOPHENE; CHROMOPHORES; MARKERS;
D O I
10.1002/adma.201304602
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An efficacious strategy to obtain photostable hyper-bright near-IR emitting fluorescent organic nanoparticles (HIFONs) is reported. These HIFONs show excellent chemical and colloidal stability and retain their pristine nanostructure and brightness after incubation in cellular environments. They can be identified at the single particle level with a wide-field microscope, emerging as highly promising tools for applications in bio-nanotechnologies. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:2258 / 2261
页数:4
相关论文
共 23 条
[1]   The versatile thiophene: An overview of recent research on thiophene-based materials [J].
Barbarella, G ;
Melucci, M ;
Sotgiu, G .
ADVANCED MATERIALS, 2005, 17 (13) :1581-1593
[2]   Oligothiophene lsothiocyanates as a new class of fluorescent markers for biopolymers [J].
Barbarella, G ;
Zambianchi, M ;
Pudova, O ;
Paladini, V ;
Ventola, A ;
Cipriani, F ;
Gigli, G ;
Cingolani, R ;
Citro, G .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (47) :11600-11607
[3]   A two-state description of (hyper) polarizabilities of push-pull molecules based on a two-form model [J].
Barzoukas, M ;
Runser, C ;
Fort, A ;
BlanchardDesce, M .
CHEMICAL PHYSICS LETTERS, 1996, 257 (5-6) :531-537
[4]   Large quadratic hyperpolarizabilities with donor-acceptor polyenes exhibiting optimum bond length alternation: Correlation between structure and hyperpolarizability [J].
BlanchardDesce, M ;
Alain, V ;
Bedworth, PV ;
Marder, SR ;
Fort, A ;
Runser, C ;
Barzoukas, M ;
Lebus, S ;
Wortmann, R .
CHEMISTRY-A EUROPEAN JOURNAL, 1997, 3 (07) :1091-1104
[5]   Oligothiophenes as Fluorescent Markers for Biological Applications [J].
Capobianco, Massimo L. ;
Barbarella, Giovanna ;
Manetto, Antonio .
MOLECULES, 2012, 17 (01) :910-933
[6]   Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells [J].
Cherukuri, P ;
Bachilo, SM ;
Litovsky, SH ;
Weisman, RB .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (48) :15638-15639
[7]   Photothermal methods for single nonluminescent nano-objects [J].
Cognet, Laurent ;
Berciaud, Stephane ;
Lasne, David ;
Lounis, Brahim .
ANALYTICAL CHEMISTRY, 2008, 80 (07) :2288-2294
[8]   Fluorescent labeling of human mesenchymal stem cells by thiophene fluorophores conjugated to a lipophilic carrier [J].
Duca, Maria ;
Dozza, Barbara ;
Lucarelli, Enrico ;
Santi, Spartaco ;
Di Giorgio, Audrey ;
Barbarella, Giovanna .
CHEMICAL COMMUNICATIONS, 2010, 46 (42) :7948-7950
[9]   Stable luminescence from individual carbon nanotubes in acidic, basic, and biological environments [J].
Duque, Juan G. ;
Cognet, Laurent ;
Parra-Vasquez, A. Nicholas G. ;
Nicholas, Nolan ;
Schmidt, Howard K. ;
Pasquali, Matteo .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (08) :2626-2633
[10]   NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein reelin [J].
Groc, Laurent ;
Choquet, Daniel ;
Stephenson, F. Anne ;
Verrier, Daniele ;
Manzoni, Olivier J. ;
Chavis, Pascale .
JOURNAL OF NEUROSCIENCE, 2007, 27 (38) :10165-10175