Radiotherapy Is Effective for Desmoid Tumors (Aggressive Fibromatosis) - Long-Term Results of a German Multicenter Study

被引:29
作者
Kriz, Jan [1 ]
Eich, Hans Theodor [1 ]
Haverkamp, Uwe [1 ]
Seegenschmiedt, M. Heinrich [2 ]
Heide, Juergen [3 ]
Bruns, Frank [4 ]
Micke, Oliver [5 ]
机构
[1] Univ Klinikum Munster, Klin & Poliklin Strahlentherapie Radioonkol, Munster, Germany
[2] Hannover Med Sch, Strahlentherapiezentrum Hamburg, Hannover, Germany
[3] Hannover Med Sch, Strahlentherapie Hamburg Harburg, Hannover, Germany
[4] Hannover Med Sch, Klin Strahlentherapie & Spezielle Onkol, Hannover, Germany
[5] Franziskus Hosp Bielefeld, Klin Strahlentherapie & Radioonkol, Bielefeld, Germany
关键词
Desmoids; Desmoid tumors; Aggressive fibromatosis; Radiotherapy; Surgery; Multicenter study; MUSCULO-APONEUROTIC FIBROMATOSIS; RADIATION-THERAPY; PROGNOSTIC-FACTORS; COMBINED SURGERY; MANAGEMENT; EXPERIENCE; EXTREMITY; PATTERNS; SERIES; TRUNK;
D O I
10.1159/000362398
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Desmoids (aggressive fibromatosis) are defined as benign neoplasms of the connective tissue that arise from the deep muscle fascia, aponeurosis, tendons, and scar tissue. Recurrence rates between 40 and 80% were reported after surgery alone. We addressed the impact of radiation therapy (RT) in the management of aggressive fibromatosis. Patients and Methods: A large literature review was performed, and the data was compared with the results of a multicenter study of the German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD). Results: This analysis included 52 patients treated with RT. 37 patients received postoperative RT (20 patients after R2 resection and 17 patients after R1 resection). 15 patients received RI alone (6 patients with inoperable primary tumor and 9 patients with inoperable recurrent tumor). In the case of postoperative RI, a median dose of 50 Gy (range 50-60 Gy) was used; for definitive RT, a median dose of 55 Gy (range 55-65 Gy) was used. The local control rate was 79% for the whole group. The median follow-up was 44 month (range 8-62 months). Conclusion: Given the large number of patients, these data show that RI is highly effective in the treatment of desmoid tumors. RT is an attractive alternative to mutilating surgery.
引用
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页码:255 / +
页数:5
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