Risk of subsequent attention deficit-hyperactivity disorder in children with febrile seizures

被引：12

作者：

Ku, Yi-Chia ^{[1
,2
]}

Muo, Chih-Hsin ^{[3
]}

Ku, Chin-Shein ^{[4
]}

Chen, Chao-Huei ^{[1
]}

Lee, Wen-Yuan ^{[5
,6
,7
]}

Shen, Ein-Yiao ^{[2
,5
]}

Chang, Yen-Jung ^{[3
,8
]}

Kao, Chia-Hung ^{[6
,7
,9
,10
]}

机构：

[1] Taichung Vet Gen Hosp, Dept Pediat, Taichung, Taiwan

[2] China Med Univ, Grad Inst Acupuncture Sci, Taichung 404, Taiwan

[3] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[4] Natl Taiwan Univ Hosp, Yunlin Branch, Dept Pediat, Taipei, Taiwan

[5] China Med Univ Hosp, Taipei Branch, Taipei, Taiwan

[6] China Med Univ, Coll Med, Grad Inst Clin Med Sci, Taichung 404, Taiwan

[7] China Med Univ, Coll Med, Sch Med, Taichung 404, Taiwan

[8] Natl Taiwan Normal Univ, Dept Hlth Promot & Hlth Educ, Taipei, Taiwan

[9] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[10] China Med Univ Hosp, PET Ctr, Taichung, Taiwan

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2014年 / 99卷 / 04期

关键词：

IRON-DEFICIENCY; DEFICIT/HYPERACTIVITY DISORDER; PROGENITOR CELLS; ASSOCIATION; CONVULSIONS; VALIDATION; NATIONWIDE; OUTCOMES; HISTORY;

D O I：

10.1136/archdischild-2013-304647

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective In this study, we obtained relevant data from a nationwide cohort database to investigate the risk of attention deficit-hyperactivity disorder (ADHD) in children with a history of febrile seizures (FS). Methods We identified 1081 children with FS as the case cohort, and the date of diagnosis was used as an index date. Four controls were matched randomly with each case based on age, sex, urbanisation level, parents' occupation, and index date. We applied Cox's proportional hazards regression to estimate the HR and CI of FS-associated ADHD. Results After 11 years of follow-up, the incidence of ADHD for the FS and control cohorts is 7.83 and 4.72 per 1000 person-years, respectively. The FS cohort was 1.66 times more at risk of ADHD occurrence (95% CI 1.27 to 2.18) than the control cohort. The risk of developing ADHD increased in conjunction with the frequency of FS-related visits. Conclusions FS may increase the risk of subsequent ADHD occurrence in children. Children who visited physicians for FS more than twice had a significantly higher cumulative incidence of ADHD.

引用

页码：322 / 326

页数：5

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