Chemical Constituents from Seeds of Panax ginseng: Structure of New Dammarane-Type Triterpene Ketone, Panaxadione, and HPLC Comparisons of Seeds and Flesh

被引:27
作者
Sugimoto, Sachiko [1 ]
Nakamura, Seikou [1 ]
Matsuda, Hisashi [1 ]
Kitagawa, Niichiro [2 ]
Yoshikawa, Masayuki [1 ]
机构
[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan
[2] Koshiro Co Ltd, Chou Ku, Osaka 5410045, Japan
关键词
panaxadione; Panax ginseng; dammarane-type triterpene; ginseng seed; Araliaceae; NOTOGINSENG BURK CHEN; F.H; FLOWER-BUDS; BIOACTIVE SAPONINS; MEDICINAL FLOWERS; CAMELLIA-SINENSIS; SOLANUM-LYCOCARPUM; AMERICAN GINSENG; QUINQUEFOLIUM-L; DRIED ROOT; GLYCOSIDES;
D O I
10.1248/cpb.57.283
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A new dammarane-type triterpene ketone, panaxadione, was isolated from the seeds of Panax ginseng C. A. MEYER (Araliaceae) together with two dammarane-type and lupane-type triterpenes, an aromatic oligoglycoside, three sterol glycosides, and three dammarane-type triterpene oligoglycosides (ginsenosides Rd, Re, and Rg(2)). The structure of a new compound was elucidated on the basis of physicochemical evidence. The relative contents of major ginsenosides in the seeds were compared with those of the flesh parts of young and mature fruits.
引用
收藏
页码:283 / 287
页数:5
相关论文
共 35 条
[1]  
Angelika L., 2005, PHYTOCHEMISTRY, V66, P2381
[2]   MECHANISM OF CYTOTOXIC ACTION OF SOME TRITERPENE GLYCOSIDES [J].
ANISIMOV, MM ;
SHENTSOVA, EB ;
SCHEGLOV, VV ;
SHUMILOV, YN ;
RASSKAZOV, VA ;
STRIGINA, LI ;
CHETYRINA, NS ;
ELYAKOV, GB .
TOXICON, 1978, 16 (03) :207-218
[3]   Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae) [J].
Hu, Jiang-Ning ;
Zhu, Xue-Mei ;
Han, Li-Kun ;
Saito, Masato ;
Sun, Yin-Shi ;
Yoshikawa, Masayuki ;
Kimura, Yoshiyuki ;
Zheng, Yi-Nan .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (01) :12-16
[4]   Cytotoxic triterpenes from the twigs of Celtis philippinensis [J].
Hwang, BY ;
Chai, HB ;
Kardono, LBS ;
Riswan, S ;
Farnsworth, NR ;
Cordell, GA ;
Pezzuto, JM ;
Kinghorn, AD .
PHYTOCHEMISTRY, 2003, 62 (02) :197-201
[5]  
Kim Seong-Ki, 1994, Journal of Plant Biology, V37, P441
[6]  
KITAGAWA I, 1989, CHEM PHARM BULL, V37, P2961, DOI 10.1248/cpb.37.2961
[7]   Enzymatic synthesis of two ginsenoside Re-β-xylosides [J].
Ko, SR ;
Suzuki, Y ;
Kim, YH ;
Choi, KJ .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2001, 65 (05) :1223-1226
[8]  
LI SH, 2004, JANPR, V4, P147
[9]   Saponins from the roots of Panax notoginseng [J].
Ma, WG ;
Mizutani, M ;
Malterud, KE ;
Lu, SL ;
Ducrey, B ;
Tahara, S .
PHYTOCHEMISTRY, 1999, 52 (06) :1133-1139
[10]  
Matsuda H, 2007, HETEROCYCLES, V71, P331