Unconventional TLC systems in lipophilicity determination: A review

被引：9
作者：
Wicha-Komsta, Katarzyna [1 ]
Komsta, Lukasz [1 ]
机构：
[1] Med Univ Lublin, Dept Med Chem, Jaczewskiego 4, PL-20090 Lublin, Poland
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2017年 / 40卷 / 5-6期
关键词：
Impregnated plates; lipophilicity; polar stationary phases; QSRR; salting-out chromatography; thin-layer chromatography; THIN-LAYER-CHROMATOGRAPHY; S-TRIAZINE DERIVATIVES; N-SUBSTITUTED; 2-ALKYLIDENE-4-OXOTHIAZOLIDINES; CALCULATED PHYSICOCHEMICAL PARAMETERS; PERFORMANCE LIQUID-CHROMATOGRAPHY; DIFFERENT COMPUTATION METHODS; DANSYLATED AMINO-ACIDS; MOBILE-PHASE MODIFIER; REVERSED-PHASE; RETENTION BEHAVIOR;
D O I：
10.1080/10826076.2017.1298023
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This review focuses on four unusual thin-layer chromatography (TLC) approaches for the determination of lipophilicity: (1) the use of medium-polar stationary phases: CN, NH2, and DIOL instead of RP plates, together with water-based mobile phase; (2) the use of silica gel in a typical normal-phase manner and treating extrapolated retention indices as the "reversed lipophilicity"; (3) the use of oil impregnated silica gel in the reversed-phase manner; and (4) the use of salting-out mobile phases. The chromatographic indices obtained in these systems are numerously reported as well correlated with lipophilicity and they are an interesting alternative to classical RP systems approaches. [GRAPHICS] .
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收藏
页码：219 / 225
页数：7
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