NEUROGENESIS AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE

被引：6

作者：

Fernandez-Verdecia, C. I. ^{[3
]}

Diaz del Guante, M. A. ^{[1
]}

Castillo-Diaz, L. ^{[2
]}

Alvarez-Blanco, J. ^{[4
]}

机构：

[1] Univ Veracruzana, Inst Invest Psicol, Lab Neurociencia Restaurat, Xalapa 91190, Veracruz, Mexico

[2] Lab Cult Tejidos, Havana, Cuba

[3] Lab Biomodelos, Havana, Cuba

[4] Ctr Int Restaurac Neurol CIREN, Havana, Cuba

来源：

REVISTA DE NEUROLOGIA | 2009年 / 49卷 / 04期

关键词：

Alzheimer's disease; Environment; Hippocampus; Neurogenesis; Progenitor cell; Transplant; NEURAL STEM-CELLS; TRANSGENIC MOUSE MODEL; HIPPOCAMPAL NEUROGENESIS; SUBVENTRICULAR ZONE; ADULT NEUROGENESIS; PROGENITOR CELLS; CEREBRAL-CORTEX; RADIAL GLIA; AGED RAT; PROLIFERATION;

D O I：

10.33588/rn.4904.2008632

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction. The adult brain of mammals preserves the capacity to generate new neurons front neural stem/progenitor cells. The new neurons become part of the already-existing networks by means of a process called 'neurogenesis in the adult brain', which is restricted to regions of the brain with a high degree of plasticity and which are associated to functions that are impaired in Alzheimer's disease. Development. Despite increasing knowledge, there are still many, questions surrounding these neurogenic phenomena, their regulation and their real therapeutic potential in cases of neurodegeneration such as the one referred to here. Conclusions. We have reviewed the subject of neurogenesis of the adult brain from both the pre-clinical point of view (experimental modelling) and the therapeutic perspective within the framework of Alzheimer's disease. [REV NEUROL 2009; 49: 193-201]

引用

页码：193 / 201

页数：9

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