Synthesis and Cytotoxicity of A-Azepanobetulinic Acid N-Methyl-Piperazinylamide

被引：13
作者：
Giniyatullina, Gulnara V. [1 ]
Kazakova, Oxana B. [1 ]
Baikova, Irina P. [1 ]
Yamansarov, Emil Yu. [2 ]
Osterman, Ilya A. [2 ,3 ,4 ]
Komarova, Ekaterina S. [2 ,3 ]
Skvortsov, Dmitry A. [2 ]
Saltikova, Irina V. [2 ]
Majouga, Alexander G. [2 ,5 ,6 ]
Ivanenkov, Yan A. [7 ,8 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, Prospekt Oktyabrya 71, Ufa 450054, Russia
[2] Lomonosov Moscow State Univ, Dept Chem, Moscow, Russia
[3] Skolkovo Inst Sci & Technol, Moscow, Russia
[4] Natl Res Univ Higher Sch Econ, Moscow, Russia
[5] Natl Univ Sci & Technol MISiS, Moscow, Russia
[6] Dmitry Mendeleev Univ Chem Technol Russia, Moscow, Russia
[7] RAS, IBG, Ufa Sci Ctr, Ufa, Russia
[8] State Univ, Moscow Inst Phys & Technol, Dolgoprudnyi, Russia
来源：
NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 07期
基金：
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词：
lupane triterpenoids; -azepanobetulinic acid; piperazinylamide; Beckmann rearrangement; cytotoxicity; antibacterial activity; BIOLOGICAL EVALUATION; OLEANOLIC ACID; DERIVATIVES;
D O I：
10.1177/1934578X19860670
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of A-azepanobetulinic acid N-methylpiperazinylamide was performed through a series of transformations (oximation, Beckmann rearrangement, reduction) of previously synthesized betulonic acid N-methylpiperazinylamide. In vitro cytotoxic activity was detected for the obtained compound against a number of cancer cell lines, and its potential was revealed as an antibacterial agent.
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页数：5
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