Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

被引：58

作者：

Bleicher, KH

Gerber, F

Wüthrich, Y

Alanine, A

Capretta, A ^{[1
]}

机构：

[1] Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada

[2] Hoffmann La Roche Ag, CH-4070 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 43期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(02)01839-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted imidazoles can be prepared efficiently from cyclic or acyclic 1,2-aminoalcohols via a four-step procedure involving acylation of the amine, oxidation of the alcohol, imine formation and cyclization. Examples are presented and the methodology is applied in the generation of a library of compounds containing a fused imidazole-azepine motif. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7687 / 7690

页数：4

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