Crosstalk between RNA m6A Modification and Non-coding RNA Contributes to Cancer Growth and Progression

被引：67

作者：

Dai, Fengsheng ^{[1
,3
]}

Wu, Yongyan ^{[1
,2
,4
]}

Lu, Yan ^{[5
]}

An, Changming ^{[6
]}

Zheng, Xiwang ^{[1
,2
]}

Dai, Li ^{[1
,3
]}

Guo, Yujia ^{[1
,2
]}

Zhang, Linshi ^{[7
]}

Li, Huizheng ^{[8
]}

Xu, Wei ^{[9
,10
,11
]}

Gao, Wei ^{[1
,2
,3
,4
]}

机构：

[1] Shanxi Med Univ, Hosp 1, Shanxi Key Lab Otorhinolaryngol Head & Neck Canc, Taiyuan 030001, Peoples R China

[2] Shanxi Med Univ, Hosp 1, Shanxi Prov Clin Med Res Ctr Precis Med Head & Ne, Taiyuan 030001, Peoples R China

[3] Shanxi Med Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Taiyuan 030001, Peoples R China

[4] Shanxi Med Univ, Minist Educ, Key Lab Cellular Physiol, Taiyuan 030001, Peoples R China

[5] Jinzhou Med Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Jinzhou 121001, Peoples R China

[6] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Canc Hosp, Dept Head & Neck Surg, Beijing 100021, Peoples R China

[7] Zhejiang Univ, Affiliated Hosp 2, Dept Thyroid Surg, Hangzhou 310009, Peoples R China

[8] Dalian Med Univ, Dalian Municipal Friendship Hosp, Dept Otolaryngol Head & Neck Surg, Dalian 116100, Peoples R China

[9] Shandong Univ, Shandong Prov ENT Hosp, Dept Head & Neck Surg, Jinan 250022, Peoples R China

[10] Shandong Prov Inst Otolaryngol, Jinan 250022, Peoples R China

[11] Shandong Univ, Minist Hlth, Key Lab Otolaryngol, Jinan 250022, Peoples R China

来源：

MOLECULAR THERAPY-NUCLEIC ACIDS | 2020年 / 22卷

基金：

中国国家自然科学基金;

关键词：

MESSENGER-RNA; COLORECTAL-CANCER; CIRCULAR RNAS; METTL3; PROMOTES; EMERGING ROLES; BREAST-CANCER; LUNG-CANCER; NUCLEAR-RNA; N-6-METHYLADENOSINE; N6-METHYLADENOSINE;

D O I：

10.1016/j.omtn.2020.08.004

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

N6-methyladenosine (m(6)A) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of m6A regulators can lead to an imbalance in m(6)A levels in cancer cells, leading to the dysregulated expression of oncogenes and tumor suppressor genes that may contribute to cancer development, patient response to chemoradiotherapy, and clinical prognosis. Recent studies demonstrate that non-coding RNAs are involved in epigenetic modification of both DNA and RNA in tumor cells, and may also affect the development and progression of cancer by targeting m(6)A regulators. In this review, we describe the functional crosstalk between m(6)A and non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, and illustrate their roles in tumor regulation. Finally, we discuss the significance of non-coding RNA and m(6)A modification in the diagnosis, treatment, and prognosis of cancer patients, as well as potential future research directions.

引用

页码：62 / 71

页数：10