Successful therapy of refractory pyoderma gangrenosum and periorbital phlegmona with tacrolimus (FK506) in ulcerative colitis

被引：23

作者：

Baumgart, DC ^{[1
]}

Wiedenmann, B ^{[1
]}

Dignass, AU ^{[1
]}

机构：

[1] Humboldt Univ, Sch Med, Charite Med Ctr,Univ Hosp Rudolf Virchow, Dept Med,Div Hepatol & Gastroenterol, D-13344 Berlin, Germany

来源：

INFLAMMATORY BOWEL DISEASES | 2004年 / 10卷 / 04期

关键词：

IBD; tacrolimus; FK506; immunosuppressants; extraintestinal manifestations;

D O I：

10.1097/00054725-200407000-00014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We describe two male patients with ulcerative colitis and refractory pyoderma gangrenosum including periorbital phlegmona in one case. Both patients were successfully managed with low dose oral tacrolimus (0.1 mg/kg bodyweight per day). Serum trough levels were closely monitored and maintained between 4 and 6 ng/mL. A rapid response was noted in both cases. Complete non-scarring skin restitution without side effects was accomplished in both cases. Low dose oral tacrolimus provides a valuable alternative treatment option for IBD patients with refractory pyoderma gangrenosum.

引用

页码：421 / 424

页数：4

共 45 条

[1]

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