Glycosphingolipids in engineered mice: insights into function

被引：46

作者：

Furukawa, K ^{[1
]}

Tokuda, N ^{[1
]}

Okuda, T ^{[1
]}

Tajima, O ^{[1
]}

Furukawa, K ^{[1
]}

机构：

[1] Nagoya Univ, Sch Med, Dept Biochem 2, Showa Ku, Nagoya, Aichi 4660065, Japan

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 04期

关键词：

glycosphingolipids; glycosyltransferase; targeting; mutant; knock-out; disease model; raft;

D O I：

10.1016/j.semcdb.2004.03.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent success in the cloning of glycosyl-transferase genes involved in the synthesis of GSLs has enabled us to modulate the expression profiles of GSLs in cultured cells and experimental animals, and allowed novel approaches to obtain clear elucidation of individual enzyme products by observing the resulting phenotypic changes in the mutant animals and transfected cells. In this review, recent progress in the study of glycosyltransferases involved in the synthesis and modification of GSLs has been summarized with special emphasis on their function. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：389 / 396

页数：8

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