Biosynthesis inspired Diels-Alder route to pyridines: synthesis of the 2,3-dithiazolylpyridine core of the thiopeptide antibiotics

被引：62

作者：

Moody, CJ ^{[1
]}

Hughes, RA

Thompson, SP

Alcaraz, L

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

[2] AstraZeneca, R&D Charnwood, Dept Med Chem, Loughborough LE11 5RH, Leics, England

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 16期

关键词：

D O I：

10.1039/b204868j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of serine derived 1-alkoxy-2-azadienes with dehydroalanine derived dienophiles results in Diels-Alder reaction and aromatisation to give 2,3,6-trisubstituted pyridines, thereby establishing the viability of the proposed biosynthetic route to the pyridine ring of the thiopeptide antibiotics originally proposed by Bycroft and Gowland.

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页码：1760 / 1761

页数：2

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