Fluid intake and risk of bladder cancer in the Nurses' Health Studies

被引:20
作者
Zhou, Jiachen [1 ,2 ]
Kelsey, Karl T. [1 ,3 ]
Giovannucci, Edward [4 ,5 ,6 ,7 ]
Michaud, Dominique S. [1 ,8 ]
机构
[1] Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA
[2] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA
[3] Brown Univ, Sch Med, Dept Pathol & Lab Med, Providence, RI 02912 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[6] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
[7] Harvard Univ, Sch Med, Boston, MA USA
[8] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Fac Med, London, England
关键词
cohort study; fluid intake; bladder cancer; smoking; women; water; FOOD FREQUENCY QUESTIONNAIRE; NATIONAL DEATH INDEX; CIGARETTE-SMOKING; BY-PRODUCTS; CONSUMPTION; REPRODUCIBILITY; EXPOSURE; VALIDITY; COHORT; WATER;
D O I
10.1002/ijc.28764
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Increase in fluid intake may reduce bladder cancer risk by decreasing the contact time between carcinogens in urine and bladder epithelium. However, this association has not been examined in a large cohort of women. The association between total fluid intake and bladder cancer risk in two large prospective women's cohorts with 427 incident bladder cancer cases was examined. Detailed information on total fluid intake was collected by repeated food frequency questionnaires over time. Multivariable relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated by using Cox proportional hazards regression models. Results from the two cohorts were pooled together using the random-effects model. Using the average values from the earliest two dietary assessments and lowest quartile as reference, a suggestive inverse association was observed between total fluid intake and overall bladder cancer risk (RR: 0.83, 95% CI: 0.61-1.12, p-value for trend: 0.08), and invasive bladder cancer risk (RR: 0.47, 95% CI: 0.23-0.97, p-value for trend: 0.04). Among heavy cigarette smokers, women with the highest quartile of total fluid intake had a 38% decrease in bladder cancer risk (RR: 0.62, 95% CI: 0.41-0.93, p-value for trend: 0.02). The findings suggested that total fluid intake may reduce bladder cancer risk for female smokers, as well as reduce the risk of invasive bladder cancer.
引用
收藏
页码:1229 / 1237
页数:9
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