Whole sorghum flour improves glucose tolerance, insulin resistance and preserved pancreatic islets function in obesity diet-induced rats

被引：19

作者：

Moraes, Erica Aguiar ^{[1
]}

Marineli, Rafaela da Silva ^{[1
]}

Lenquiste, Sabrina Alves ^{[1
]}

Vieira Queiroz, Valeria Aparecida ^{[2
]}

Camargo, Rafael Ludemann ^{[3
]}

Borck, Patricia Cristine ^{[3
]}

Carneiro, Everardo Magalhaes ^{[3
]}

Marostica Junior, Mario Roberto ^{[1
]}

机构：

[1] Univ Estadual Campinas, Fac Food Engn, Dept Food & Nutr, Campinas, SP, Brazil

[2] Brazilian Agr Res Corp, Embrapa Maize & Sorghum, Sete Lagos, MG, Brazil

[3] Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP, Brazil

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 45卷

关键词：

Sorghum bicolor; Decorticated grain; Bran; Phenolic compounds; Oxidative stress; Diabetes; ANTIOXIDANT CAPACITY; SUPEROXIDE-DISMUTASE; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; EXTRACT EXERTS; FAT; PLASMA; ASSAYS; CHOLESTEROL; POLYPHENOLS;

D O I：

10.1016/j.jff.2017.03.047

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The effects of sorghum flour fractions (whole and decorticated flours and bran) were evaluated for oxidative stress and obesity parameters in diet-induced obese rats. Compared to high fat-fructose groups, sorghum flour fractions reduced liver fat and whole sorghum flour decreased fasting glucose, improved glucose tolerance, insulin resistance and reduced insulin secretion. Sorghum showed a slight improvement in antioxidant status. Animals fed with sorghum flour fractions improved liver CAT, GRd and GPx activities and decreased plasma lipid peroxidation. Additionally, whole sorghum flour can be used as a strategy to ameliorate glucose/insulin homeostasis by increasing insulin sensitivity, leading to pancreatic islet function preservation in a prediabetic condition. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：530 / 540

页数：11

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