Impact of the MTHFR C677T Polymorphism on Risk of Wilms Tumor Case-Control Study

被引：16

作者：

Ferrara, Mara ^{[1
]}

Capozzi, Laura ^{[1
]}

Russo, Rosa ^{[1
]}

机构：

[1] Univ Naples 2, Dept Pediat, Naples, Italy

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2009年 / 31卷 / 04期

关键词：

Wilms tumor; MTHFR C677T genotype; folate; BECKWITH-WIEDEMANN-SYNDROME; METHYLENETETRAHYDROFOLATE-REDUCTASE GENE; METHYLATION; HYPOMETHYLATION; DNA; EXPRESSION; KCNQ1OT1; MUTATION; DEFECTS; CANCER;

D O I：

10.1097/MPH.0b013e318196a40c

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Methylentetrahydrofolate reductase C677T genotype was assessed in 35 patients of both sexes aged between 3.2 and 5.4 years affected by Wilms tumor (WT) and in 70 random controls. Statistical analysis was performed comparing frequency of WT methylentetrahydrofolate reductase genotypes with 70 controls and a larger Italian population. The homozygous TT and heterozygous CT genotypes were associated with a significantly higher frequency of WT than CC genotype, By reducing tissue folate concentrations and inducing hypomethylation both TT and CT genotypes could be risk factors for WT (odds ratio > 1).

引用

页码：256 / 258

页数：3

共 25 条

[1] Epigenotyping as a tool for the prediction of tumor risk and tumor type in patients with Beckwith-Wiedemann syndrome (BWS) [J].