Early Erythrolysis in the Hematoma After Experimental Intracerebral Hemorrhage
被引:99
作者:
Dang, Ge
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机构:
Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Guangdong, Peoples R ChinaUniv Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Dang, Ge
[1
,2
]
Yang, Yuefan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian, Peoples R ChinaUniv Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Yang, Yuefan
[1
,3
]
Wu, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USAUniv Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Wu, Gang
[1
]
Hua, Ya
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USAUniv Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Hua, Ya
[1
]
Keep, Richard F.
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h-index: 0
机构:
Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USAUniv Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Keep, Richard F.
[1
]
Xi, Guohua
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h-index: 0
机构:
Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Univ Michigan, R5018 BSRB, 109 Zina Pitcher Pl, Ann Arbor, MI 48109 USAUniv Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
Xi, Guohua
[1
,4
]
机构:
[1] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Guangdong, Peoples R China
[3] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian, Peoples R China
[4] Univ Michigan, R5018 BSRB, 109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA
Erythrolysis occurs in the clot after intracerebral hemorrhage (ICH), and the release of hemoglobin causes brain injury, but it is unclear when such lysis occurs. The present study examined early erythrolysis in rats. ICH rats had an intracaudate injection of 100 mu l autologous blood, and sham rats had a needle insertion. All rats had T2 and T2* magnetic response imaging (MRI) scanning, and brains were used for histology and CD163 (a hemoglobin scavenger receptor) and DARPP-32 (a neuronal marker) immunohistochemistry. There was marked heterogeneity within the hematoma on T2* MRI, with a hyperintense or isointense core and a hypointense periphery. Hematoxylin and eosin staining in the same animals showed significant erythrolysis in the core with the formation of erythrocyte ghosts. The degree of erythrolysis correlated with the severity of perihematomal neuronal loss. Perihematomal CD163 was increased by day 1 after ICH and may be involved in clearing hemoglobin caused by early hemolysis. Furthermore, ICH resulted in more severe erythrolysis, neuronal loss, and perihematomal CD163 upregulation in spontaneously hypertensive rats compared to Wistar-Kyoto rats. In conclusion, T2*MRI-detectable early erythrolysis occurred in the clot after ICH and activated CD163. Hypertension is associated with enhanced erythrolysis in the hematoma.
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Ji, Nan
Lu, Jing Jing
论文数: 0引用数: 0
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机构:
Capital Med Univ, Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Lu, Jing Jing
Zhao, Yuan Li
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Zhao, Yuan Li
Wang, Shuo
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h-index: 0
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Wang, Shuo
Zhao, Ji Zong
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Li, Zhe
Liu, Yang
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Liu, Yang
Wei, Ruixue
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Wei, Ruixue
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机构:
Khan, Suliman
Zhang, Ruiyi
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhang, Ruiyi
Zhang, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
机构:
Columbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
Ironside, Natasha
Chen, Ching-Jen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Neurol Surg, Charlottesville, VA USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
Chen, Ching-Jen
Ding, Dale
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机构:
Univ Louisville, Sch Med, Dept Neurol Surg, Louisville, KY 40292 USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
Ding, Dale
Mayer, Stephan A.
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Syst, Dept Neurol, Detroit, MI USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
Mayer, Stephan A.
Connolly, Edward Sander, Jr.
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h-index: 0
机构:
Columbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Ji, Nan
Lu, Jing Jing
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Lu, Jing Jing
Zhao, Yuan Li
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Zhao, Yuan Li
Wang, Shuo
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
Wang, Shuo
Zhao, Ji Zong
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R ChinaCapital Med Univ, Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Li, Zhe
Liu, Yang
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Liu, Yang
Wei, Ruixue
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Wei, Ruixue
论文数: 引用数:
h-index:
机构:
Khan, Suliman
Zhang, Ruiyi
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhang, Ruiyi
Zhang, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
机构:
Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China
Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R ChinaZhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
机构:
Columbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
Ironside, Natasha
Chen, Ching-Jen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Dept Neurol Surg, Charlottesville, VA USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
Chen, Ching-Jen
Ding, Dale
论文数: 0引用数: 0
h-index: 0
机构:
Univ Louisville, Sch Med, Dept Neurol Surg, Louisville, KY 40292 USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
Ding, Dale
Mayer, Stephan A.
论文数: 0引用数: 0
h-index: 0
机构:
Henry Ford Hlth Syst, Dept Neurol, Detroit, MI USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA
Mayer, Stephan A.
Connolly, Edward Sander, Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USAColumbia Univ, Med Ctr, Dept Neurol Surg, 710 W,168th St, New York, NY 10032 USA