A retrospective examination of sporozoite-induced and trophozoite-induced infections with Plasmodium ovale:: Development of parasitologic and clinical immunity during primary infection

被引:30
作者
Collins, WE [1 ]
Jeffery, GM [1 ]
机构
[1] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA 30341 USA
关键词
D O I
10.4269/ajtmh.2002.66.492
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A retrospective analysis was made of clinical and parasitologic parameters in patients with induced Plasmodium ovate infection to document the initial clinical and parasitologic response and their subsequent development of clinical and parasitologic immunity, and to determine the effect of previous homologous and heterologous malaria on subsequent infection with this parasite. The prepatent periods were relatively uniform. Eight patients injected with sporozoites that had been stored frozen had a median prepatent period of 14 days (range = 14-20 days). Thirty-five patients infected via the bites of infected mosquitoes had a median prepatent period of 15 days (range = 12-18 days). In eight patients previously infected with P. vivax, the median prepatent period was 16 days. High-intensity fever (greater than or equal to 104degreesF) was frequently seen, with instances of fever greater than or equal to 106'F recorded on many occasions. Fever > 101degreesF and > 104degreesF occurred for much shorter periods of time than had been observed in patients infected with P. falciparum. Parasite counts > 10,000/muL were infrequent; in most patients, such parasite counts rarely lasted more than two or three days. Gametocytemia was generally of low density and lasted only a few days. The overall length of the clinical and parasitologic period was much shorter compared with that seen in patients infected with P. falciparum. Previous infection with P. ovate did not prevent reinfection, but resulted in reduced levels of parasitemia and fever. Previous infection with heterologous species of Plasmodium did not prevent infection; some reduction in the frequency and intensity of fever and parasite counts was evident. Previous infection with homologous or heterologous parasites failed to eliminate the production of infective gametocytes. A total of 462 lots of mosquitoes were fed on 67 patients with no previous history of infection. Of these feedings, 168 (36.4%) resulted in infection as determined by the presence of oocysts on the midguts of dissected mosquitoes. As shown, the infection rate increased with the density of gametocytes even though 48 (23.4%) of 205 lots of mosquitoes fed when no gametocytes were detected were infected.
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收藏
页码:492 / 502
页数:11
相关论文
共 14 条
[1]   A retrospective examination of the patterns of recrudescence in patients infected with Plasmodium falciparum [J].
Collins, WE ;
Jeffery, GM .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 61 (01) :44-48
[2]   A retrospective examination of sporozoite- and trophozoite-induced infections with Plasmodium falciparum:: Development of parasitologic and clinical immunity during primary infection [J].
Collins, WE ;
Jeffery, GM .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 61 (01) :4-19
[3]   A retrospective examination of secondary sporozoite- and trophozoite-induced infections with Plasmodium falciparum:: Development of parasitologic and clinical immunity following secondary [J].
Collins, WE ;
Jeffery, GM .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 61 (01) :20-35
[4]   A retrospective examination of sporozoite- and trophozoite-induced infections with Plasmodium falciparum in patients previously infected with heterologous species of Plasmodium:: Effect on development of parasitologic and clinical immunity [J].
Collins, WE ;
Jeffery, GM .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1999, 61 (01) :36-43
[5]  
COLLINS WE, 1962, P 49 ANN M NEW JERS, P188
[6]  
EARLE WC, 1932, J LAB CLIN MED, V17, P1124
[7]  
GARNHAM P. C. C., 1955, TRANS ROY SOC TROP MED AND HYG, V49, P158, DOI 10.1016/0035-9203(55)90042-0
[8]  
Jeffery G. M., 1955, Experimental Parasitology, V4, P445, DOI 10.1016/0014-4894(55)90036-9
[9]  
JEFFERY G. M., 1955, TRANS ROY SOC TROP MED AND HYG, V49, P168, DOI 10.1016/0035-9203(55)90043-2