Transcription Factor Bhlhe40 in Immunity and Autoimmunity

被引：71
作者：
Cook, Melissa E. [1 ]
Jarjour, Nicholas N. [2 ]
Lin, Chih-Chung [3 ,4 ]
Edelson, Brian T. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[2] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
[3] Massachusetts Gen Hosp, Dept Neurol, Mass Gen Inst Neurodegenerat Dis, Genet & Aging Res Unit, Charlestown, MA USA
[4] Harvard Med Sch, Charlestown, MA USA
来源：
TRENDS IN IMMUNOLOGY | 2020年 / 41卷 / 11期
基金：
美国国家科学基金会;
关键词：
T-CELLS; B-CELLS; MACROPHAGE PROLIFERATION; NEGATIVE REGULATOR; INTERFERON-GAMMA; GENE-EXPRESSION; MARGINAL ZONE; SELF-RENEWAL; FACTOR DEC1; SCID MICE;
D O I：
10.1016/j.it.2020.09.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The basic helix-loop-helix transcription factor (TF) Bhlhe40 is emerging as a key regulator of immunity during infection, autoimmunity, and inflammatory conditions. We describe the roles of Bhlhe40 in the circulating and tissue-resident arms of the immune system, with emphasis on recent work on the regulation of cytokine production and proliferation. We explore the mechanisms behind these functions in mouse models and human cells, including interactions with other TFs, and propose that Bhlhe40 is a central mediator of both inflammation and pathogen control, as well as a crucial regulator of a growing number of tissue-resident leukocyte populations. Finally, we suggest areas for further study that may advance our understanding of immunity and disease.
引用
收藏
页码：1023 / 1036
页数：14
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