Lactate and the Mechanism of Hypoglycemia-Associated Autonomic Failure in Diabetes

被引：4
作者：
Arbelaez, Ana Maria [1 ]
Cryer, Philip E. [2 ]
机构：
[1] Washington Univ, Sch Med, Dept Pediat, Div Endocrinol & Diabet, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA
来源：
DIABETES | 2013年 / 62卷 / 12期
关键词：
VENTROMEDIAL HYPOTHALAMUS CONTRIBUTES; ANTECEDENT HYPOGLYCEMIA; NORMAL HUMANS; SUBSEQUENT HYPOGLYCEMIA; BLOOD LACTATE; BRAIN; RESPONSES; COUNTERREGULATION; METABOLISM; SYMPTOMS;
D O I：
10.2337/db13-1360
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：3999 / 4001
页数：3
相关论文
共 22 条
[1]  
Antenor-Dorsey JAV, 2013, DIABETES, V62, pA100
[2]   The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy [J].
Boumezbeur, Fawzi ;
Petersen, Kitt F. ;
Cline, Gary W. ;
Mason, Graeme F. ;
Behar, Kevin L. ;
Shulman, Gerald I. ;
Rothman, Douglas L. .
JOURNAL OF NEUROSCIENCE, 2010, 30 (42) :13983-13991
[3]   Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory reponses after antecedent Hypoglycemia [J].
Chan, Owen ;
Cheng, Haiying ;
Herzog, Raimund ;
Czyzyk, Daniel ;
Zhu, Wanling ;
Wang, Ajin ;
McCrimmon, Rory J. ;
Seashore, Margretta R. ;
Sherwin, Robert S. .
DIABETES, 2008, 57 (05) :1363-1370
[4]   Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes [J].
Chan, Owen ;
Paranjape, Sachin A. ;
Horblitt, Adam ;
Zhu, Wanling ;
Sherwin, Robert S. .
DIABETES, 2013, 62 (12) :4239-4246
[5]   Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats [J].
Chan, Owen ;
Paranjape, Sachin ;
Czyzyk, Daniel ;
Horblitt, Adam ;
Zhu, Wanling ;
Ding, Yuyan ;
Fan, Xiaoning ;
Seashore, Margretta ;
Sherwin, Robert .
DIABETES, 2011, 60 (05) :1582-1589
[6]   Insulin Reciprocally Regulates Glucagon Secretion in Humans [J].
Cooperberg, Benjamin A. ;
Cryer, Philip E. .
DIABETES, 2010, 59 (11) :2936-2940
[7]  
Cryer P.E., 2012, Hypoglycemia in Diabetes
[8]   Mechanisms of Hypoglycemia-Associated Autonomic Failure in Diabetes [J].
Cryer, Philip E. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (04) :362-372
[9]   HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE IN INSULIN-DEPENDENT DIABETES-MELLITUS - RECENT ANTECEDENT HYPOGLYCEMIA REDUCES AUTONOMIC RESPONSES TO, SYMPTOMS OF, AND DEFENSE AGAINST SUBSEQUENT HYPOGLYCEMIA [J].
DAGOGOJACK, SE ;
CRAFT, S ;
CRYER, PE .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (03) :819-828
[10]   Effects of differing antecedent hypoglycemia on subsequent counterregulation in normal humans [J].
Davis, SN ;
Shavers, C ;
MosquedaGarcia, R ;
Costa, F .
DIABETES, 1997, 46 (08) :1328-1335
123