Clinical evaluation of photodynamic therapy efficacy in the treatment of oral leukoplakia

被引:45
作者
Pietruska, Malgorzata [1 ]
Sobaniec, Stefan [1 ]
Bernaczyk, Piotr [2 ]
Cholewa, Magdalena [1 ]
Pietruski, Jan Krzysztof [2 ]
Dolinska, Ewa [1 ]
Skurska, Anna [1 ,2 ]
Duraj, Ewa [1 ]
Tokajuk, Grazyna [1 ]
机构
[1] Med Univ Bialystok, Dept Periodontal & Oral Mucosa Dis, PL-15269 Bialystok, Poland
[2] Med Univ Bialystok, Dept Med Pathomorphol, PL-15269 Bialystok, Poland
关键词
Oral leukoplakia; Photodynamic therapy; TOPICAL 5-AMINOLEVULINIC ACID; PREMALIGNANT LESIONS; ERYTHROPLAKIA; SURGERY; CANCERS; CAVITY; LASER;
D O I
10.1016/j.pdpdt.2013.10.003
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The aim of the study was clinical evaluation of photodynamic therapy efficacy in the treatment of oral leukoplakia lesions. Methods: Twenty-three consecutive patients aged 21-79 were included to the study. In all patients 44 homogeneous, flat leukoplakia lesions were clinically diagnosed and confirmed histopathologically. Photodynamic therapy was performed with the use of Photo (R) photosensitizer, containing 20% Chlorine-e6 and 10% dimethyl sulfoxide and a semiconductor laser, with power up to 300 mW and a wavelength of 660 nm. Ten illumination sessions were conducted with the use of superficial light energy density of 90 J/cm(2). Results: At baseline the mean size of leukoplakia lesion was 6.5 +/- 5.10 cm(2) while after photodynamic therapy 3 +/- 2.99 cm(2). Significant reduction (on average by 53.8%) of leukoplakia lesions sizes was observed after therapy. Twelve (27.27%) lesions had been completely cured, 22 (50%) partially cured, although 10 (22.73%) lasted unchanged. The efficacy of PTD was comparable in women and men irrespective of age. There have been no adverse site effects during therapy noted. Conclusions: Within the limits of the study it can be concluded that photodynamic therapy with the use of Chlorine-e6 can lead to considerable reduction of oral leukoplakia lesions size thus may be useful in clinical practice. However there is a need of further studies on larger number of cases and longer follow-up time. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:34 / 40
页数:7
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