Leptin: New hope for the treatment of post-operative cognitive dysfunction?

被引：0

作者：

Hua, Fei ^{[1
]}

Yang, Chun ^{[2
]}

Zhu, Bin ^{[3
]}

机构：

[1] Soochow Univ, Affiliated Hosp 3, Dept Endocrinol, Changzhou, Peoples R China

[2] Soochow Univ, Affiliated Hosp 3, Dept Anesthesiol, Changzhou, Peoples R China

[3] Soochow Univ, Affiliated Hosp 3, Dept Crit Care Med, Changzhou, Peoples R China

来源：

MEDICAL SCIENCE MONITOR | 2014年 / 20卷

关键词：

Alzheimer Disease; Autophagy; Leptin; Postoperative Complications; ALZHEIMERS-DISEASE; AGED RATS; ANESTHESIA; HOMEOSTASIS; UPDATE; WOMEN; AMPK; BETA;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Leptin plays a critical role in neuronal development and also promotes structural and functional activities in the central nervous system. Recent studies have demonstrated that leptin could produce therapeutic effects for cognitive impairments of patients with Alzheimer's disease (AD). Post-operative cognitive dysfunction (POCD), defined as a significant dysfunction in cognitive performance for several weeks after surgery, probably has a pathogenesis similar to that of AD. Specifically, they are both characterized by cognitive impairment. In this regard, we hypothesized that leptin probably has a therapeutic benefit of alleviating symptoms of patients with POCD, and the leptin signaling pathway may be involved in the pathogenesis of POCD.

引用

页码：866 / 868

页数：3

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