TGF-β: Duality of Function Between Tumor Prevention and Carcinogenesis

被引：429

作者：

Principe, Daniel R. ^{[1
,3
,5
]}

Doll, Jennifer A. ^{[6
]}

Bauer, Jessica ^{[1
]}

Jung, Barbara ^{[1
]}

Munshi, Hidayatullah G. ^{[2
]}

Bartholin, Laurent ^{[7
]}

Pasche, Boris ^{[8
]}

Lee, Chung ^{[4
,9
]}

Grippo, Paul J. ^{[3
]}

机构：

[1] Northwestern Univ Feinberg Sch Med, Dept Med, Div Gastroenterol, Chicago, IL 60611 USA

[2] Northwestern Univ Feinberg Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA

[3] Northwestern Univ Feinberg Sch Med, Dept Surg, Div GI Surg Oncol, Chicago, IL 60611 USA

[4] Northwestern Univ Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA

[5] Northwestern Univ, Dept Biomed Engn, McCormick Sch Engn, Evanston, IL 60208 USA

[6] Univ Wisconsin, Dept Biomed Sci, Milwaukee, WI 53201 USA

[7] Univ Lyon 1, Ctr Rech Cancerol Lyon, UMR INSERM U1052, CNRS 5286, F-69365 Lyon, France

[8] Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA

[9] Univ Calif Irvine, Dept Pathol & Lab Med, Irvine, CA USA

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2014年 / 106卷 / 02期

关键词：

GROWTH-FACTOR-BETA; REGULATORY T-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; PROSTATE-CANCER CELLS; TRANSFORMING GROWTH-FACTOR-BETA-1; PANCREATIC-CANCER; E-CADHERIN; EXTRACELLULAR-MATRIX; ADOPTIVE TRANSFER; TRANSGENIC MICE;

D O I：

10.1093/jnci/djt369

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several mechanisms underlying tumor progression have remained elusive, particularly in relation to transforming growth factor beta (TGF-beta). Although TGF-beta initially inhibits epithelial growth, it appears to promote the progression of advanced tumors. Defects in normal TGF-beta pathways partially explain this paradox, which can lead to a cascade of downstream events that drive multiple oncogenic pathways, manifesting as several key features of tumorigenesis (uncontrolled proliferation, loss of apoptosis, epithelial-to-mesenchymal transition, sustained angiogenesis, evasion of immune surveillance, and metastasis). Understanding the mechanisms of TGF-beta dysregulation will likely reveal novel points of convergence between TGF-beta and other pathways that can be specifically targeted for therapy.

引用

页数：16

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