CD20 antibodies induce production and release of reactive oxygen species by neutrophils

被引:10
作者
Werlenius, Olle [1 ,2 ]
Riise, Rebecca E. [1 ,3 ]
Simpanen, Maria [1 ,2 ]
Aurelius, Johan [1 ,3 ]
Thoren, Fredrik B. [1 ,3 ]
机构
[1] Univ Gothenburg, Sahlgrenska Canc Ctr, Sahlgrenska Acad, S-40530 Gothenburg, Sweden
[2] Univ Gothenburg, Sahlgrenska Canc Ctr, Dept Hematol, S-40530 Gothenburg, Sweden
[3] Univ Gothenburg, Sahlgrenska Canc Ctr, Dept Infect Dis, S-40530 Gothenburg, Sweden
关键词
NK CELLS; RITUXIMAB; CYTOTOXICITY;
D O I
10.1182/blood-2014-05-574285
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:4001 / 4002
页数:2
相关论文
共 6 条
[1]  
Bylund J, 2014, METHODS MOL BIOL, V1124, P321, DOI 10.1007/978-1-62703-845-4_21
[2]   Rituximab-dependent cytotoxicity by natural killer cells:: Influence of FCGR3A polymorphism on the concentration-effect relationship [J].
Dall'Ozzo, S ;
Tartas, S ;
Paintaud, G ;
Cartron, G ;
Colombat, P ;
Bardos, P ;
Watier, H ;
Thibault, G .
CANCER RESEARCH, 2004, 64 (13) :4664-4669
[3]  
Golay J, 2003, HAEMATOLOGICA, V88, P1002
[4]   Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab [J].
Golay, Josee ;
Da Roit, Fabio ;
Bologna, Luca ;
Ferrara, Claudia ;
Leusen, Jeanette H. ;
Rambaldi, Alessandro ;
Klein, Christian ;
Introna, Martino .
BLOOD, 2013, 122 (20) :3482-3491
[5]  
HELLSTRAND K, 1994, J IMMUNOL, V153, P4940
[6]   The CD16-/CD56bright subset of NK cells is resistant to oxidant-induced cell death [J].
Thoren, Fredrik B. ;
Romero, Ana I. ;
Hermodsson, Svante ;
Hellstrand, Kristoffer .
JOURNAL OF IMMUNOLOGY, 2007, 179 (02) :781-785