Clinical implications of molecular heterogeneity in triple negative breast cancer

被引：91

作者：

Lehmann, Brian D. ^{[1
]}

Pietenpol, Jennifer A. ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Biochem, Nashville, TN 37232 USA

来源：

BREAST | 2015年 / 24卷

关键词：

Chemotherapy; TNBCtype; Neoadjuvant; PIK3CA; Androgen receptor; TUMOR-INFILTRATING LYMPHOCYTES; COMPLETE RESPONSE RATES; NEOADJUVANT CHEMOTHERAPY; PHASE-II; STAGE-II; CARBOPLATIN; BEVACIZUMAB; EXPRESSION; MUTATIONS; SUBTYPES;

D O I：

10.1016/j.breast.2015.07.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Triple negative breast cancer (TNBC) is a molecularly heterogeneous disease lacking recurrent targetable alterations and thus therapeutic advances have been challenging. The absence of ER, PR and HER2 amplifications, leaves combination chemotherapy as the standard of care treatment option in the adjuvant, neoadjuvant and metastatic settings. Recently, multiple studies have shed some light on the heterogeneity of TNBC and identified distinct transcriptional subtypes with unique biologies. Herein we review the molecular heterogeneity and the impact on previous and future clinical trials. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：S36 / S40

页数：5

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