Polysaccharides based superabsorbent hydrogel from Linseed: Dynamic swelling, stimuli responsive on-off switching and drug release

被引：94

作者：

Huseeb, Muhammad T. ^{[1
,3
]}

Hussain, Muhammad A. ^{[2
]}

Yuk, Soon H. ^{[3
]}

Bashir, Sajid ^{[1
]}

Nauman, Muhammad ^{[2
]}

机构：

[1] Univ Sargodha, Fac Pharm, Sargodha 40100, Pakistan

[2] Univ Sargodha, Dept Chem, Sargodha 40100, Pakistan

[3] Korea Univ, Coll Pharm, Sejong 339700, South Korea

来源：

CARBOHYDRATE POLYMERS | 2016年 / 136卷

关键词：

Linseed hydrogel; Superporous hydrogel; Polysaccharides; Swelling-deswelling; Drug release; IN-VITRO EVALUATION; SUSTAINED-RELEASE; SUPERPOROUS HYDROGELS; DELIVERY-SYSTEMS; FLAXSEED HULLS; PH-SENSITIVITY; POLYMERS; POLYACRYLAMIDE; MECHANISMS; KINETICS;

D O I：

10.1016/j.carbpol.2015.09.092

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Swelling properties of Linseed hydrogel (LSH) were studied in deionized water and different physiological pH values, i.e., 1.2, 6.8 and 7.4. Analysis of the kinetics drawn from swelling data has revealed that swelling of LSH followed second order kinetics. The results indicated that swelling of LSH is greatly affected by different concentration of salts. Stimuli responsive on-off switching of LSH was studied in water/normal saline, water/ethanol and basic/acidic environment and found reversible. LSH swells maximum in water and at pH 7.4 while deswells abruptly in ethanol and at pH 1.2. The elongated porous structures uniformly organized in layers were observed in FE-SEM. LSH was used as a sustained release material for tablet formulation of diclofenac sodium. Drug release study followed non-Fickian diffusion. LSH sustained the release of drug even better than a commercially available formulation of diclofenac sodium. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：750 / 756

页数：7

共 33 条

[1]

Barbary O M., 2009, J Adv Agric Res, V14, P605

[2] Mechanisms of solute and drug transport in relaxing, swellable, hydrophilic glassy polymers [J].

Brazel, CS ;

Peppas, NA .

POLYMER, 1999, 40 (12) :3383-3398

[3] Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin [J].

Chavanpatil, Mahesh D. ;

Jain, Paras ;

Chaudhari, Sachin ;

Shear, Rajesh ;

Vavia, Pradeep R. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 316 (1-2) :86-92

[4]

Gupta NV, 2010, DARU, V18, P200

[5] pH and ionic strength responsive photonic polymers fabricated by using colloidal crystal templating [J].

Huang, Jing ;

Hu, Xiaobin ;

Zhang, Weixia ;

Zhang, Yihe ;

Li, Guangtao .

COLLOID AND POLYMER SCIENCE, 2008, 286 (01) :113-118

[6] pH-sensitive cationic guar gum/poly (acrylic acid) polyelectrolyte hydrogels: Swelling and in vitro drug release [J].

Huang, Yihong ;

Yu, Huiqun ;

Xiao, Chaobo .

CARBOHYDRATE POLYMERS, 2007, 69 (04) :774-783

[7] Evaluation of hot-water extracted arabinoxylans from ispaghula seeds as drug carriers [J].

Iqbal, Mohammad S. ;

Akbar, Jamshed ;

Hussain, Muhammad A. ;

Saghir, Shazia ;

Sher, Muhammad .

CARBOHYDRATE POLYMERS, 2011, 83 (03) :1218-1225

[8] MECHANISMS OF SOLUTE RELEASE FROM POROUS HYDROPHILIC POLYMERS [J].

KORSMEYER, RW ;

GURNY, R ;

DOELKER, E ;

BURI, P ;

PEPPAS, NA .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1983, 15 (01) :25-35

[9] Analysis of Responsive Characteristics of Ionic-Strength-Sensitive Hydrogel with Consideration of Effect of Equilibrium Constant by a Chemo-Electro-Mechanical Model [J].

Li, Hua ;

Lai, Fukun ;

Luo, Rongmo .

LANGMUIR, 2009, 25 (22) :13142-13150

[10] Surface characterization and drug release from porous microparticles based on methacrylic monomers and xanthan [J].

Lungan, Maria-Andreea ;

Popa, Marcel ;

Racovita, Stefania ;

Hitruc, Gabriela ;

Doroftei, Florica ;

Desbrieres, Jacques ;

Vasiliu, Silvia .

CARBOHYDRATE POLYMERS, 2015, 125 :323-333

← 1 2 3 4 →